Based on advanced technology, Creative Biolabs can provide numerous corneal wound healing models for our global customers to study the corneal wound healing process. Our professional scientists have worked in the field of preclinical investigation for many years, thus we guarantee our clients will get the most reliable and satisfactory service at a competitive price.
What Is Corneal Wound?
The cornea is the most anterior part of the eye and normal visual function is strongly dependent on an intact corneal surface. Eye injuries such as physical or chemical trauma or severe infections may result in permanent corneal damage leading to opacification and loss of visual acuity. Thus, rapid restoration of corneal integrity after injury is key to prevent intraocular inflammation that can cause permanent loss of vision or even loss of the eye itself.
Corneal Wound Healing Model
Corneal wound healing is a critical process for restoring corneal integrity and maintaining vision after corneal injury. It involves a series of cellular events, such as cell death, migration, proliferation, differentiation, and extracellular matrix remodeling. Elucidating the molecular mechanisms that underlie the proper closure of corneal wounds is important for the development of novel treatments to promote healing and to the clinical management of epithelial lesions. In the past years, several models of wound healing such as rabbits and rodents have been developed to investigate the corneal mechanisms of reepithelialization and to screen growth factors that may stimulate a healthy healing response. Moreover, many new in vitro models also generated by mimicking the cornea in vivo gives a new way to study cellular and molecular mechanisms implicated in wound healing.
Fig.1 Schematic representation of the corneal wound healing mechanism. (Chaurasia S S, 2015)
Establishment of Corneal Wound Healing Model
Based on the theory that the repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms, most corneal wound healing models are generated by taking a series of measures leading to corneal epithelial defects. For this purpose, a corneal wound of 6mm in diameter was introduced into the corneal of test animals using a trephine to mark the wound area. Then the corneal epithelium was removed with a dull-bladed knife. In addition, care should be taken to avoid damage to deeper corneal layers.
Our Capabilities
At Creative Biolabs, we can provide rodent in vivo wound healing models for our worldwide customers. Furthermore, we also offer in vitro models as well as customized models to meet specific requirements of our clients. To fully characterize the efficacy of test substance to promote corneal wound healing, we have developed a series of assessments, which including but not limited to:
Additionally, Creative Biolabs also offers other types of ocular disease models that you may be interested in:
If you are interested in our cornel wound healing model, please do not hesitate to contact us or send us an inquiry. We are happy to share our cutting-edge technology and sufficient expertise to assist your research.
Reference
For Research Use Only.
