Creative Biolabs has a wealth of experiences and capabilities to provide corneal neovascularization model and service for our worldwide clients to accelerate their preclinical study development. Based on incomparable technique platforms and professional team of scientists, we guarantee our clients the most reliable and efficient services to ensure their project a success.
What Is Corneal Neovascularization?
Corneal neovascularization (NV) refers to the growth of blood vessels or lymphatics into the physiologically avascular cornea. It is a common and serious complication of many corneal diseases including inflammatory disorders, infectious keratitis, contact-lens-related hypoxia, alkali burns, stromal ulceration and limbal stem cell deficiency. Moreover, it can result in lipid exudation, persistent inflammation, and scarring, which will disrupt corneal transparency and visual acuity.
Corneal Neovascularization Model
The visibility, accessibility, and avascularity of cornea enable it a well-established site for observing the angiogenic response. Plus, corneal neovascularization model provides an efficient method to evaluate the angiogenic and antiangiogenic properties of both ocular and non-ocular compounds. In recent years, the field of angiogenesis research is expanding rapidly, and the assessment of angiogenic responses to different molecules becomes increasingly important. Therefore, several effective, reliable and reproducible models have been established to accelerate preclinical development. These methods including but not limited to intrastromal injections of substances, chemical injuries, and sutures.
Fig.1 Common experimental approaches to induce corneal NV in mice. Red arrows represent lymphatics, green arrows represent blood vessels. (Kather J N, 2014)
Our Capabilities
Over the past years, we have developed a better understanding of the key mechanisms in corneal neovascularization. Our professional scientists enable us to provide numerous frequently used approaches for NV model creation, including corneal pocket assay, suture injury model, chemical injury by alkali burn, and spontaneous transgenic model. Moreover, we will take a series of measures, which includes but not limited to a comparison of the test article to currently approved therapeutics, observations of changes in corneal structure, tissue harvest and histopathological examination to fully evaluate the relative efficacy of test articles.
In addition, Creative Biolabs offers other related rodent ocular disease models that you might interest in.
Creative Biolabs is committed to being your good partner in the drug discovery development process. To meet specific requirements of worldwide customers, we also provide customized service. Please feel free to contact us to get an inquiry and more detail, we'll get in touch with you as soon as possible.
Reference
For Research Use Only.
