Dry eye syndrome also known as keratoconjunctivitis sicca (KCS), is an increasingly prevalent condition that affects tens of millions of people all over the world. The ocular dryness and discomfort associated with dry eye disease can progress to visual disturbance and instability of the tear film, potentially leading to damage to the ocular surface. Unfortunately, the precise mechanisms of dry eye syndrome were not fully understood. Therefore, the appropriate animal model is necessary to reflect the pathogenesis or the molecular mechanisms of dry eye disease. Creative Biolabs has developed validated dry eye model to help our worldwide clients better investigate the mechanism and therapeutic study design of dry eye syndrome.
The cause of dry eye can be divided into quantitative, qualitative, and combined tear film deficiency, and they can be induced by differently pathophysiologic mechanisms. To promote the research and development of new ocular medicines and devices, many animal models for studying special forms of dry eye have been developed to mimic these different mechanisms in the past years. However, almost each dry eye model has specific characteristic and limitation. Understanding the characteristics and limitations of these models will help researchers choose the right models to address specific problems and develop new treatment modalities in dry eye.
Fig. 1 The conjunctival goblet cells demonstrated by Periodic acid-Schiff stain were reduced in the controlled-environment chamber (CEC)-induced dry eye.1
Establishment of Dry Eye Model
Dry eye model can be induced using atropine, preservative Benzalkonium Chloride and low humidity conditions in rodents or using a novel ophthalmic airflow chamber. In addition, surgical procedures, such as excising lacrimal glands, can also create dry eye model. The existing animal models involve different animal species like monkey, rabbit, rat, mice, dog, and mouse. Moreover, several genetically modified or spontaneous mouse models have been proposed for dry eye diseases. Having worked in the field of rodent disease models many years, Creative Biolabs can provide both the standard and genetically modified animal models for our worldwide clients.
Our Capabilities
At Creative Biolabs, our professional team has years of experience utilizing ophthalmic animal models for drug development. We also have extensive experience in various routes of administration and can customize studies depending on your needs. In addition, we conduct a full range of measurements to ensure the modeling outcomes as well as investigating drug efficacy, including but not limited to:
Except for dry eye model, we can also provide other related rodent ocular disease models for worldwide clients. If you are interested in the services we can provide, please click the links below.
Creative Biolabs is committed to offering high-quality service with our advanced technology for worldwide customers. Our experienced scientists will help you with every step of your project at most favorable prices currently on the market. To get more detailed information or a formal quote, please feel free to contact us.
Reference
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