Rodent Ocular Disease Models

Introduction

As a global leader in preclinical ophthalmic research, Creative Biolabs offers numerous ocular disease models for worldwide clients to enable directed and meaningful preclinical drug discovery and development programs. Our experienced experts can help you select the right model and assay with extensive information on each eye disease model. In addition, we can provide custom studies to meet the specific needs of a particular compound or discovery project.

Ocular Disease Models Available at Creative Biolabs

Creative Biolabs can provide numerous rodent research models to enable directed and meaningful preclinical drug discovery and development programs. With extensive experience, we conduct each model coupled with different parameters that can be used to evaluate the efficacy of candidate drugs. Importantly, our professional team which is supported by internal PK/Bioanalytical, ex vivo pharmacology and in vitro biology experts will work closely with you to ensure the most reliable data can be achieved. To learn more details about different ocular disease models, you can click on the links below:

Fig.1 From gene discovery to therapy of retinal degenerative diseases.¹

Our Capabilities

At Creative Biolabs, we understand that innovative ocular disease model development is essential for your drug's success. With meticulous research and objective interpretation of data, our experienced Ph.D. and M.D. study directors perform standard guidelines and work closely with Creative Biolabs's other preclinical development multidisciplinary teams to advance your compound and device innovations.

• Animals: Mouse, Rat, Rabbit, NHPs
• Route of administration: Eye drops, anterior chamber injection, intravitreal injection, subretinal injection, suprachoroidal injection, retrobulbar injection
• Eye tissue sampling: cornea, conjunctiva, iris, lens, retina, choroid, optic nerve, aqueous humor, vitreous, whole blood, plasma, serum, tears
• Ophthalmological examination
  • Slit lamp examination
  • Direct/indirect ophthalmoscopy
  • Fundus photography (FP)
  • Optical coherence tomography (OCT)
  • Fundus fluorescein angiography (FFA)
  • Fundus infrared/autofluorescence imaging
  • Intraocular pressure test
  • Semi-quantitative preclinical ocular toxicity score (SPOTS)

  • Laser photocoagulation
  • Flash visual evoked potential (f-VEP)
  • Flash electroretinogram (f-ERG)
  • Corneal injury fluorescence test
  • Corneal sensitivity test
  • Optomotor response test (OMR)
  • Draize test

Creative Biolabs is happy to share our top-notch technology and abundant experience with global customers. Before the initial start of model creation, we will conduct stringent pre-screening ophthalmic exams to eliminate pre-existing ocular defects that could adversely affect the outcome of your ocular studies. If you are interested in the service we can provide, please feel free to contact us or send us an inquiry.

Reference

1. Veleri S, et al. Biology and therapy of inherited retinal degenerative disease: insights from mouse models. Disease models & mechanisms, 2015, 8(2): 109-129.

For Research Use Only.