Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSL-(Dsred) (RepOV-0055WQ)

This product is a Dsred encoding oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSL
Transgene Dsred
Type of Transgene Reporter gene
Related Target/Protein Discosoma red fluorescent protein
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine
Transgene
Alternative Names DsRed, Discosoma red fluorescent protein
Information
Introduction Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when excited. Several variants have been developed using directed mutagenesis. The original was isolated from Discosoma, and named DsRed. Others are now available that fluoresce orange, red, and far-red.RFP is approximately 25.9 kDa. The excitation maximum is 558 nm, and the emission maximum is 583 nm.
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