To fully optimize oncolytic virotherapy and provide meaningful mechanistic insight, it is important to have representative animal models of oncolysis in various tumor types. Xenograft animal models for oncolytic virus preclinical studies are crucial in validating toxicology and efficacy of novel oncolytic viral therapy. Creative Biolabs offers a variety of xenograft animal models, which are applicable to a variety of oncolytic viruses.
Creative Biolabs provides a variety of immuno-compromised animal models that are permissive to oncolytic virus infection, including nude, nod-scid, and NSG mice. Different oncolytic viruses can infect different animal species, such as mouse, rat, rabbit, dog, and monkey. Creative Biolabs can develop customized animal models for POC and toxicology studies depending on the virus type.
During the development of oncolytic virus drugs, the efficacy and toxicology studies need to be tested using syngeneic tumor models. Scientists in Creative Biolabs have developed these tumor models in immuno-competent animals.
Murine or human cancer cell lines have been used widely to establish suitable tumor models to evaluate the efficacy and toxicity of oncolytic viral therapy. Creative Biolabs has established both murine and human cancer cell lines for tumor model studies. These tumor cell lines have also been engineered with GFP, luciferase expression, for in vivo imaging.
In addition, we are readily able to create cell derived xenograft (CDX) models owing to close collaborations with hospitals around the world and thus easy access to patient primary cancer cells.
Please feel free to contact us for a quote and further discussion with our scientists.