Welcome to Creative Biolabs
Creative Biolabs as a contract research organization is a leading provider of oncolytic virus development services. Our service covers all aspects from virus engineering, cell biology to animal testing with a special emphasis on virus engineering and in vitro and in vivo validation. Creative Biolabs has a team of experienced scientists, we have developed a comprehensive set of technologies allowing clients to tailor the development process to their specific needs.
At Creative Biolabs, we provide a full list of purified oncolytic virus products as reference agents to be tested in vitro and in vivo studies. Also, every product of oncolytic virus can be used as a backbone for further engineering and modification to meet the specific needs of our clients. All the products are accessible by searching on our website through categories under virus species or specific modifications. With their expertise and dedication to innovation, Creative Biolabs is well-positioned to continue leading the way in developing cutting-edge therapies for patients with cancer.
OUR SERVICES
Oncolytic Virus Engineering
We offer a comprehensive oncolytic virus engineering platform that can be tailored to meet specific research, preclinical study, and drug development needs. Our research team provides the technologies to manipulate the virus to reduce pathogenicity and immunogenicity, boost the anti-tumor immune response, attract immune cells to the tumor site, and even load immune checkpoint inhibitors.
Oncolytic Virus Construction
Our oncolytic virus engineering scope is extensive and includes a variety of viruses such as Adenovirus, Herpes Simplex Virus, Measles Virus, Vaccinia Virus, Vesicular Stomatitis Virus, and Adeno-Associated Virus. These viruses are manipulated by our team of experts to create innovative therapies for cancer treatment, aimed at improving patient outcomes and revolutionizing traditional chemotherapy and radiation treatments.
One-Stop Oncolytic Virus Enhancement
Creative Biolabs is an ideal partner for global customers seeking oncolytic vaccinia virus enhancement services. With years of expertise in the development of oncolytic vaccinia virus, our one-stop service can greatly contribute to the success of your projects. Our team of experts offers the best advice and support to advance your programs and ensure high-quality results.
Oncolytic Virus in vitro Validation Study
Creative Biolabs provides a diverse range of in vitro assay services for engineered oncolytic viruses to test their functional activity. Our proof-of-concept assays include plaque purification, identity, replication, tumor lytic, transgene expression, and transgene functional assays, among others. These assays are designed to ensure the safety and efficacy of the oncolytic virus and provide critical data for drug development and clinical trials.
Oncolytic Virus in vivo Preclinical Study
Creative Biolabs offers a variety of in vivo preclinical study services to test the safety and efficacy of engineered oncolytic viruses. These include constructing animal models, immunogenicity tests, biodistribution/PK tests, efficacy, and toxicology studies. Preclinical assessment is crucial due to the different safety, tumor sensitivity, and toxicity of different oncolytic viruses, as well as the impact of immune system mechanisms. Our team has developed preclinical in vivo assays for both murine and human cancer models and can provide efficacy and toxicity data suitable for Investigational New Drug (IND) application.
Disease-Specific Oncolytic Virotherapy
Creative Biolabs is committed to developing immunotherapy strategies and reagents for various cancers, including melanoma, genitourinary malignancies, hepatocellular carcinoma, breast cancer, and brain cancer, among others. Our OncoVirapy™ platform, based on oncolytic virus, is used as the lead in developing disease-specific immunotherapy strategies. The recombinant virus undergoes in vitro assays to test its replication capacity, tumor cell killing ability, and expression and function of the transgene, followed by in vivo validation of therapeutic effects in related disease models. Proof-of-concept studies for combination therapeutic strategies are also available.
Combination Therapy with Cancer Immunotherapy
Creative Biolabs provides one-stop oncolytic virotherapy development for combination cancer immunotherapy using a comprehensive cancer therapy platform that combines oncolytic virotherapy with various forms of cancer immunotherapy. Oncolytic viruses are engineered or selected to propagate in and selectively kill cancer cells, and combining them with conventional anti-cancer therapies has been shown to improve therapeutic responses. With extensive experience in oncolytic virotherapy and cancer immunotherapy, Creative Biolabs offers potential therapeutic approaches for various types of disease.
What's New
Creative Biolabs is proud to exhibit and participate in industry conferences where our scientists showcase innovative drug discovery solutions. Whether you are diving into scientific research, biopharmaceutical discovery and development, or industrial manufacturing, we strongly encourage you to come and meet us at our coming conferences! Our experts are excited to meet with our clients in person to discuss how we can assist in the development and optimization of your new drug discovery.