Pre-made Oncolytic Vaccinia Virus

Pre-made Oncolytic Vaccinia Virus

Oncolytic viruses are a class of antitumor agents that selectively kill tumor cells without affecting normal cells. Vaccinia virus (VACV) is a large, enveloped virus that is considered as the most potential live biotherapeutic agent because of its strong oncolytic efficacy and potent antigen presentation capability that can combine well with its natural oncolytic activities for cancer immunotherapy. Many types of modified vaccinia virus have been used for in vitro and in vivo studies, as well as clinical trials. Creative Biolabs provides one-stop services by utilizing advanced a broad range of gene therapy platform.

Vaccinia virus can accommodate more than 30 kb of foreign DNA. Foreign genes can be stably integrated into the viral genome, resulting in efficient and long-term gene expression. The deletion of the viral genes of thymidine kinase (TK) and vaccinia growth factors (VGF) results in enhanced tumor-selectively and antitumor activity, and reduced virus virulence. In addition, as immunoregulatory genes the deletion of the viral genes of F1L and E3L can enhance an immune response to a poxvirus vaccine, thereby breaking the immune tolerance of tumor cells. Modified vaccinia viruses can be engineered to express various immunizing antigens and used for cancer treatment, including breast cancer, colorectal cancer, prostate cancer, pancreatic cancer, glioblastoma and lung cancer. Creative Biolabs provides multiple modified purified oncolytic vaccinia virus products derived from different strains covering demands for gene therapy all over the world.

Features of Our Products

  • Rapid design and construction
  • Functional validations
  • Non-toxic and safe in human
  • Low cost
  • Customized services

Relying on the vaccinia virus construction technology platform, Creative Biolabs utilizes advanced biomolecular techniques and gene knockout techniques to provide design and construction services suitably and accurately for oncolytic vaccinia virus, and small to large-scale production with robust quality control for the worldwide clients. The design and construction of oncolytic vaccinia virus including knockout one or multiple genes in genome, and insert foreign genes by using the appropriate promoters. Except for the following existing products, we provide customized oncolytic VACV construction services to meet the specific need of our clients. We will provide comprehensive consultation on the design of oncolytic vaccinia virus. Please feel free to contact us for details.

All products and services are for Research Use Only. Not For Clinical Use.

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