Palm-Glu(OSu)-OtBu Albumin Binding Conjugation Reagent (CAT#: OLY-1023-YS178)

Description

This reagent is designed to covalently attach a palmitic acid (C16) albumin-binding motif to a molecule. It uses a glutamic acid scaffold. The N-terminus is acylated with palmitic acid. The gamma-carboxyl is protected as an acid-labile t-butyl (OtBu) ester. The alpha-carboxyl is activated as an amine-reactive N-hydroxysuccinimide (OSu) ester. This allows for the direct, one-step conjugation of the C16-lipid tail (which binds non-covalently to albumin) onto a primary amine of a drug or peptide, extending its in vivo half-life.

Molecular Weight

538.73

Purity

>96.0%

Formula

C₂₉H₅₀N₂O₇

Product Type

Albumin Binding Conjugation Reagents

Group 1

NHS

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, -20°C

Molecular Structure