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Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (scFv-CH3) (CAT#: BSFC-073)
Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD3 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CLEC12A scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML) therapy.
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