Home > Products > CD3 & CLEC12A > Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (scFv-IgG)

Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (scFv-IgG)  (BSSG-073)

Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD3 antibody variable domain are respectively connected to the N terminus of the anti-CLEC12A IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget T cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML) therapy.

Specifications

Targets
CD3 & CLEC12A
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CLEC12A
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML)

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CLEC12A
Gene ID
UniProt ID
Alternative Names
CLEC12A; C-type lectin domain family 12, member A; CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor

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