Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (VHH-Fc-VHH) (HCAB-043)

Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-DENV and anti-CD64 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget neutrophils cells to dengue virus. It is designed for the research of The Dengue virus infection therapy.

Datasheet INQUIRY

Specifications

Targets

DENV & CD64

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC)

Targets

Target 1

DENV

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Target 2

CD64

Gene ID

4233

UniProt ID

A0A024R759

Alternative Names

MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (VHH-Fc-VHH) (CAT#: HCAB-043)

Specifications

Targets

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