Home > Products > DENV & CD64 > Recombinant Human Anti-DENV x Human Anti-CD64 Bispecific Antibody (scFv4-Ig)

Recombinant Human Anti-DENV x Human Anti-CD64 Bispecific Antibody (scFv4-Ig)  (FVTIG-H316)

Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-DENV scFv is fused to the CH1 domain of a heavy chain and another anti-CD64 scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget neutrophils cells to dengue virus. It is designed for the research of Dengue virus infection therapy.

Specifications

Targets
DENV & CD64
Type
Appended IgGs
Species Reactivity
Human
Target 1
DENV
Host Animal 1
Human
Target 2
CD64
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Dengue virus infection

Targets

Target 1
DENV
Alternative Names
dengue virus; DENV; dengue fever; Flavivirus
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI

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