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Ang2 & VEGFA Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Diabody) Human Ang2 VEGFA Inquiry
T-BSDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Diabody) Human Ang2 VEGFA Inquiry
SCIGG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scIgG) Human Single chain IgGs Ang2 VEGFA Inquiry
FABVC-358 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-VHH-Fc) Human Fab-Fc Fusion Proteins Ang2 VEGFA Inquiry
BSSG-358 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (VHH-IgG) Human Appended IgGs Ang2 VEGFA Inquiry
HCAB-003 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (VHH-Fc-VHH) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BIBD-358 Recombinant Anti-Ang2 x Anti-VEGFA VHH BispecificAntibody (Bibody) Human Bibody Ang2 VEGFA Inquiry
IGVHH-003 Recombinant Anti-Ang2 x Anti-VEGFA VHH BispecificAntibody (IgG-VHH) Human Appended IgGs Ang2 VEGFA Inquiry
SCIGG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scIgG) Human Single chain IgGs Ang2 VEGFA Inquiry
BIVHH-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Bi-sdAb) Human Bi-sdAb Ang2 VEGFA Inquiry
FVTIG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ang2 VEGFA Inquiry
FVTIG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ang2 VEGFA Inquiry
BSSG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-IgG) Human Appended IgGs Ang2 VEGFA Inquiry
BSSG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-IgG) Human Appended IgGs Ang2 VEGFA Inquiry
IGLFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ang2 VEGFA Inquiry
IGLFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ang2 VEGFA Inquiry
BSGV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (IgG-Fv) Human IgG-Fv Ang2 VEGFA Inquiry
BSGV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-Fv) Human IgG-Fv Ang2 VEGFA Inquiry
BSDG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fv-IgG) Human Appended IgGs Ang2 VEGFA Inquiry
BSDG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fv-IgG) Human Appended IgGs Ang2 VEGFA Inquiry
BABFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ang2 VEGFA Inquiry
BABFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ang2 VEGFA Inquiry
FABVC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ang2 VEGFA Inquiry
FABVC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ang2 VEGFA Inquiry
SCDBC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
SCDBC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSDBC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSDBC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
SCDBF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
SCDBF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSFVF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSFVF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSDBF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSDBF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ang2 VEGFA Inquiry
BSTF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSTF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSCFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSCFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
MNAB-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
MNAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSFC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSFC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSCC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BSCC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Ang2 VEGFA Inquiry
BIBD-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 VEGFA Inquiry
BIBD-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 VEGFA Inquiry
FABFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 VEGFA Inquiry
FABFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 VEGFA Inquiry
MiniB-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 VEGFA Inquiry
MiniB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 VEGFA Inquiry
SCDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 VEGFA Inquiry
FABIG-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 VEGFA Inquiry
TRIB-H196 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Triple Body) Human Triple Body Ang2 VEGFA Inquiry
BSIG-H194 Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 VEGFA Inquiry
CROSSAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 VEGFA Inquiry
IGFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 VEGFA Inquiry
BSDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 VEGFA Inquiry
BSFAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 VEGFA Inquiry
BSFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 VEGFA Inquiry
SCDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 VEGFA Inquiry
FABIG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 VEGFA Inquiry
TRIB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Triple Body) Human Triple Body Ang2 VEGFA Inquiry
BSIG-008 Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 VEGFA Inquiry
CROSSAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 VEGFA Inquiry
IGFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 VEGFA Inquiry
BSDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 VEGFA Inquiry
BSFAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 VEGFA Inquiry
BSFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 VEGFA Inquiry

Background

Ang2 (angiopoietin 2) is a regulator of angiogenesis, the process of forming new blood vessels, and it promotes vessel destabilization. In contrast, VEGFA (vascular endothelial growth factor A) promotes blood vessel growth. Both Ang2 and VEGFA play critical roles in tumor angiogenesis and inflammation. The anti-Ang2×anti-VEGFA bispecific antibody (BsAb) is a novel therapeutic agent designed to simultaneously target both Ang2 and VEGFA. This BsAb blocks the activity of Ang2 and VEGFA by preventing them from interacting with their respective receptors on endothelial cells to inhibit angiogenesis, maintain blood vessel stability, and control inflammation. This BsAb holds promise in various medical fields, including cancer therapy, ocular diseases, and inflammatory disorders. It offers a potential combination therapy approach by targeting two critical factors involved in angiogenesis simultaneously.

Fig.1 A BsAb targeting Ang2 and VEGFA. (Koh, et al., 2022) Fig.1 A BsAb against Ang2 and VEGFA.1

Reference

  1. Koh, Gou Young, Hellmut G. Augustin, and Peter A. Campochiaro. "Viewpoints: Dual-blocking antibody against VEGF-A and angiopoietin-2 for treating vascular diseases of the eye." Trends in Molecular Medicine (2022).
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