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EPCAM Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
SCDBF-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Ad fiber knob Mouse EPCAM Mouse Inquiry
BSFVF-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human EPCAM Human Inquiry
BSFVF-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD28 Human EPCAM Human Inquiry
BSFVF-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse EPCAM Mouse Inquiry
BSFVF-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD28 Mouse EPCAM Mouse Inquiry
BSFVF-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Ad fiber knob Mouse EPCAM Mouse Inquiry
BSDBF-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human EPCAM Human Inquiry
BSDBF-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD28 Human EPCAM Human Inquiry
BSDBF-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse EPCAM Mouse Inquiry
BSDBF-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD28 Mouse EPCAM Mouse Inquiry
BSDBF-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Ad fiber knob Mouse EPCAM Mouse Inquiry
BSTF-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse EPCAM Mouse Inquiry
BSTF-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD28 Mouse EPCAM Mouse Inquiry
BSTF-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse EPCAM Mouse Inquiry
BSTF-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD28 Mouse EPCAM Mouse Inquiry
BSTF-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad fiber knob Mouse EPCAM Mouse Inquiry
BSCFV-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse EPCAM Mouse Inquiry
BSCFV-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse EPCAM Mouse Inquiry
BSCFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse EPCAM Mouse Inquiry
BSCFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse EPCAM Mouse Inquiry
BSCFV-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad fiber knob Mouse EPCAM Mouse Inquiry
MNAB-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse EPCAM Mouse Inquiry
MNAB-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse EPCAM Mouse Inquiry
MNAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse EPCAM Mouse Inquiry
MNAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse EPCAM Mouse Inquiry
MNAB-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody Ad fiber knob Mouse EPCAM Mouse Inquiry
BSFC-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse EPCAM Mouse Inquiry
BSFC-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse EPCAM Mouse Inquiry
BSFC-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse EPCAM Mouse Inquiry
BSFC-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse EPCAM Mouse Inquiry
BSFC-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad fiber knob Mouse EPCAM Mouse Inquiry
BSCC-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse EPCAM Mouse Inquiry
BSCC-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse EPCAM Mouse Inquiry
BSCC-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse EPCAM Mouse Inquiry
BSCC-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse EPCAM Mouse Inquiry
BSCC-004 Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad fiber knob Mouse EPCAM Mouse Inquiry
BIBD-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD3 Mouse EPCAM Mouse Inquiry
BIBD-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD28 Mouse EPCAM Mouse Inquiry
BIBD-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD3 Mouse EPCAM Mouse Inquiry
BIBD-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD28 Mouse EPCAM Mouse Inquiry
BIBD-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
FABFV-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human EPCAM Human Inquiry
FABFV-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Human EPCAM Human Inquiry
FABFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse EPCAM Mouse Inquiry
FABFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Mouse EPCAM Mouse Inquiry
FABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob Mouse EPCAM Mouse Inquiry
MiniB-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD3 Human EPCAM Human Inquiry
MiniB-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD28 Human EPCAM Human Inquiry
MiniB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD3 Mouse EPCAM Mouse Inquiry
MiniB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD28 Mouse EPCAM Mouse Inquiry
MiniB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
SCTB-H150 Recombinant Human Anti-EPCAM x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human EPCAM Human Inquiry
SCTB-H130 Recombinant Human Anti-EPCAM x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Human EPCAM Human Inquiry
SCDB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human EPCAM Human Inquiry
SCDB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Human EPCAM Human Inquiry
FABIG-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human EPCAM Human Inquiry
FABIG-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Human EPCAM Human Inquiry
TRIB-H255 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human EPCAM Human Inquiry
TRIB-H235 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human EPCAM Human Inquiry
BSIG-H253 Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human EPCAM Human Inquiry
BSIG-H233 Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human EPCAM Human Inquiry
CROSSAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 Human EPCAM Human Inquiry
CROSSAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 Human EPCAM Human Inquiry
IGFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human EPCAM Human Inquiry
IGFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human EPCAM Human Inquiry
BSDB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 Human EPCAM Human Inquiry
BSDB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 Human EPCAM Human Inquiry
BSFAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human EPCAM Human Inquiry
BSFAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human EPCAM Human Inquiry
BSFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human EPCAM Human Inquiry
BSFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human EPCAM Human Inquiry
SCTB-052 Recombinant Anti-EPCAM x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse EPCAM Mouse Inquiry
SCTB-031 Recombinant Anti-EPCAM x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse EPCAM Mouse Inquiry
SCDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse EPCAM Mouse Inquiry
SCDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse EPCAM Mouse Inquiry
SCDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
FABIG-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse EPCAM Mouse Inquiry
FABIG-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse EPCAM Mouse Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob Mouse EPCAM Mouse Inquiry
TRIB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse EPCAM Mouse Inquiry
TRIB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse EPCAM Mouse Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSIG-079 Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse EPCAM Mouse Inquiry
BSIG-059 Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse EPCAM Mouse Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob Mouse EPCAM Mouse Inquiry
CROSSAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse EPCAM Mouse Inquiry
CROSSAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse EPCAM Mouse Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob Mouse EPCAM Mouse Inquiry
IGFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse EPCAM Mouse Inquiry
IGFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse EPCAM Mouse Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 Mouse EPCAM Mouse Inquiry
BSDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 Mouse EPCAM Mouse Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSFAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse EPCAM Mouse Inquiry
BSFAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse EPCAM Mouse Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse EPCAM Mouse Inquiry
BSFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse EPCAM Mouse Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry

Background

Fig 1. EpCAM signaling in cross-talk with E-Cadherin. (Schnell, et al., 2013)Fig.1 EpCAM signaling in cross-talk with E-Cadherin.1

The epithelial cell adhesion molecule (EpCAM) is a membrane-based glycoprotein expressed by epithelial cells. It plays a crucial role in cell-cell adhesion and signaling, regulating the proliferation, differentiation, and migration of epithelial cells. EpCAM is involved in various cellular processes including embryonic growth and tissue repair. EpCAM expression has been discovered to be abnormal in several kinds of cancers, including colorectal, lung, and breast cancer. EpCAM-targeted therapies including monoclonal antibodies and CAR T cells have been developed to treat these cancers. They aim to block EpCAM-mediated signaling pathways, disrupt cell adhesion, and promote immune-mediated destruction of cancer cells. Additionally, EpCAM-based diagnostics have been developed for early cancer identification and therapy efficacy monitoring. Overall, EpCAM is an important biomarker and therapeutic target in cancer research with potential applications in diagnosis, prognosis, and treatment.

Reference

  1. Schnell, Ulrike, et al. “EpCAM: structure and function in health and disease.” Biochimica et biophysica acta vol. 1828,8 (2013): 1989-2001.
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