Home > Products > CD28 & EPCAM > Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc)

Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc)  (BSFVF-H235)

Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CD28/EPCAM tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors therapy.

Specifications
Targets
CD28 & EPCAM
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Human
Target 2
EPCAM
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
EPCAM
Gene ID
UniProt ID
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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