Home > Products > CD20 & CD22 > Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin)

Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin)  (BSFAB-BGN022)

Recombinant Anti-CD20 x Anti-CD22 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Bouganin (BGN) fused to a tandem Fab recognizing CD20 and CD22. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver BGN to antigen-specific cells. Then BGN is a single chain, type I ribosone inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease therapy.

Specifications
Targets
CD20 & CD22
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CD20
Host Animal 1
Human
Target 2
CD22
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease
Targets
Target 1
CD20
Gene ID
UniProt ID
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
Target 2
CD22
Gene ID
UniProt ID
Alternative Names
CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
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