This is an aptamer development services to screening aptamers binds to the ANGPT1 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | ANGPT1 |
| Alternative Names | Angiopoietin 1; Angiopoietin-1; KIAA0003; ANG-1; ANGPT1; AGP1; AGPT; ANG1; Ang1 |
| Gene ID | 284 |
| UniProt ID | Q15389 |
| Target Overview | This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |