Name: Anti-Human IL1B Aptamer
SKU: CTMM-0124-RJ32
Rating: 5 (1 reviews)

Specifications

Target Category	Protein
Target	IL1B
Alternative Names	Interleukin 1 Beta; IL1F2; IL1-BETA; Interleukin-1 Beta; IL-1 Beta; Catabolin; IL-1B; Pro-Interleukin-1-Beta; Preinterleukin 1 Beta; Interleukin 1beta; IL1beta; IL-1; IL1B
Gene ID	3553
UniProt ID	P01584
Target Overview	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Type	DNA
Species Reactivity	Human; Rat
Length	50-100 nt
GC Content	41.03%
Molecular Weight	23469.4 g/mole
nmoles/OD260	1.156

Anti-Human IL1B Aptamer(Cat#: CTMM-0124-RJ32)

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Anti-Human IL1B Aptamer(Cat#: CTMM-0124-RJ32)

Certificate of Analysis Lookup

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