Anti-PDCD1 aptamer(Cat#: CTApt-2051)
This product is an aptamer which binds to the CD279 with an affinity of <200 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
CD279 |
| Alternative Names |
Programmed Cell Death 1; PD1; Systemic Lupus Erythematosus Susceptibility 2; Programmed Cell Death Protein 1; Protein PD-1; CD279; HPD-1; HSLE1; PD-1; Programmed Cell Death 1 Protein; CD279 Antigen; SLEB2 ; HPD-L; PDCD1 |
| Gene ID |
5133 |
| UniProt ID |
Q15116 |
| Target Overview |
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. |
| Chemical Modification |
DNA |
| Length |
60-80 nt |
| Affinity (Kd) |
<200 nM |
| Binding Conditions/Buffer |
10 mmol/l (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) (HEPES), 150 mmol/l NaCl, 0.05% Tween-20, 1 mmol/l MgCl2, 1 mmol/l CaCl2) |
| GC Content |
0.64 |
| Molecular Weight |
22900.8 |
| nmoles/OD260 |
1.349 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
