Rat Anti-Mouse CD11b Monoclonal Antibody (CTJS-122)(Cat#: CTA-837)
This product is an unconjugated anti-Mouse CD11b Monoclonal antibody (CTJS-122) generated from the Rat. The antibody can be used for IP, IF, FC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-122 |
| Host Animal |
Rat |
| Isotype |
IgG2a |
| Immunogen |
Mouse Integrin αM from Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice |
| Species Reactivity |
Mouse |
| Applications |
IP; IF; FC |
| Application Notes |
IP: 1-2 μg/mL
IF: 1:50-1:500
FC: 1 µg/10^6 cells
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Mouse CD11b. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
100 µg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
CD11b |
| Alternative Names |
Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b |
| Gene ID |
16409 |
| UniProt ID |
P05555 |
Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
