Creative Biolabs has focused on building efficient systems and procedures to promote the drug discovery development of global customers. Based on years of experience and advanced technology, now we can provide excretion balance services including expert study designs and data interpretation which allows you to characterize your drug candidate's properties. Our professional scientists will help implement your preclinical drug discovery projects and your organization’s ability to make sound decisions towards key milestones.

Introduction of Excretion Balance Study

As an important part of in vivo ADME studies, excretion balance studies are conducted to investigate the percentage of the dose eliminated. What’s more, urinary, biliary and fecal excretions are relative importance for data analysis. Generally, the study is performed in general toxicity species (both rodent and non-rodent), later in development also in the second carcinogenicity species. With animals kept in metabolic cages, excreta are carefully collected, volume or weight recorded and total radioactivity concentration in each sample measured at various time intervals up to generally 5 or 6 days, or longer if the half-life of radioactivity is long and excretion of radioactivity is still notable. Furthermore, some samples, the ones where radioactivity is more concentrated, are appropriately treated and analyzed with chromatographic, spectrometric and radiometric systems to identify and quantify the main metabolites.

Phosphate balance in a patient receiving dialysis. Fig.1 Phosphate balance in a patient receiving dialysis. (Hutchison, et al. 2011)

Excretion Balance Study Service Provided by Creative Biolabs

Creative Biolabs carries out a wide range of studies in the field of in vivo ADME, with a top-notch knowledge in drug absorption, distribution, metabolism, and excretion. We are a true chameleon in the way we work as everything can be designed according to the customer’s needs and requirements. With extensive experience, our professional scientists have expertise in providing excretion balance services for global customers. All of the services include comprehensive study consulting, enabling us to create the ideal study plan for your needs. Furthermore, the state-of-art data quality is ensured by optimizing the conditions according to the compounds instead of using generic protocols.

Advantages

  • Extensive experience in excretion balance studies
  • Short duration and competitive price
  • Advanced platforms with professional scientists

Creative Biolabs is committed to offering in vivo PK services for global customers in the most high-quality and cost-effective way. Except for excretion balance services, we also offer other In vivo ADME services, including:

In addition to the services of in vivo ADME, you might be also interested in other in vivo PK studies listed below:

Our experienced staffs will work closely with you to accelerate the development of your drug discovery programs. If you are interested in the service we can provide, please feel free to contact us and get a quote. We will get in touch with you as soon as possible.

Reference

  1. Hutchison, et al. "Pharmacology, efficacy, and safety of oral phosphate binders." Nature Reviews Nephrology 7.10 (2011): 578.

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