Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CCR5 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD3 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget T cells to CCR5 target cells. It is designed for the research of HIV-1 infection, AIDS therapy.
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