Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Minibody) (MiniB-H206)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CCR5 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD3 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget T cells to CCR5 target cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Datasheet

Specifications

Targets

CCR5 & CD3

Type

Minibody

Species Reactivity

Human

Target 1

CCR5

Host Animal 1

Human

Target 2

CD3

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

HIV-1 infection, AIDS

Targets

Target 1

CCR5

Gene ID

1234

UniProt ID

P51681

Alternative Names

CCR5; C-C motif chemokine receptor 5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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