Home > Products > CCR5 & CD3 > Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scDiabody-CH3)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scDiabody-CH3)  (SCDBC-H206)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scDiabody-CH3) is a fusion protein of two scDiabodies connected together by a CH3 region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-CCR5/anti-CD3 diabody. The scDiabody with two specificities is fused to each of the CH3 chains to extend half-life. This BsAb can retarget T cells to CCR5 target cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications
Targets
CCR5 & CD3
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CCR5
Host Animal 1
Human
Target 2
CD3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CCR5
Gene ID
UniProt ID
Alternative Names
CCR5; C-C motif chemokine receptor 5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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