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Recombinant Human Anti-CD19 x Human Anti-CD3 Bispecific Antibody (scFv-Fc)  (BSCFV-H218)

Recombinant Anti-CD19 x Anti-CD3 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD19 specificity or anti-CD3 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Leukemia therapy.

Specifications

Targets
CD19 & CD3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD19
Host Animal 1
Mouse
Target 2
CD3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma; Follicular lymphoma; Leukemia

Targets

Target 1
CD19
Gene ID
UniProt ID
Alternative Names
CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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