Home > Products > CD28 & FOLR1 > Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-CH1/CL)

Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-CH1/CL)  (BSCC-060)

Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-CD28 antibody variable domain is fused to CH1 and the other scFv from an anti-FOLR1 antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can retarget T cells to tumor cells. It is designed for the research of Ovarian cancer; Solid tumors therapy.

Specifications
Targets
CD28 & FOLR1
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
FOLR1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Ovarian cancer; Solid tumors
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
FOLR1
Gene ID
UniProt ID
Alternative Names
FOLR1; folate receptor 1 (adult); folate receptor 1; FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
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