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NGF & TNF Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Diabody) Human NGF TNF Inquiry
T-BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Diabody) Human NGF TNF Inquiry
SCIGG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs NGF TNF Inquiry
SCIGG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs NGF TNF Inquiry
FVTIG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv4-Ig) Human Appended IgGs NGF TNF Inquiry
FVTIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv4-Ig) Human Appended IgGs NGF TNF Inquiry
BSSG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-IgG) Human Appended IgGs NGF TNF Inquiry
BSSG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-IgG) Human Appended IgGs NGF TNF Inquiry
IGLFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs NGF TNF Inquiry
IGLFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs NGF TNF Inquiry
BSGV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv NGF TNF Inquiry
BSGV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv NGF TNF Inquiry
BSDG-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fv-IgG) Human Appended IgGs NGF TNF Inquiry
BSDG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fv-IgG) Human Appended IgGs NGF TNF Inquiry
BABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins NGF TNF Inquiry
BABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins NGF TNF Inquiry
FABVC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins NGF TNF Inquiry
FABVC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins NGF TNF Inquiry
SCDBC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
SCDBC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSDBC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSDBC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
SCDBF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
SCDBF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSFVF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSFVF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSDBF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSDBF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments NGF TNF Inquiry
BSTF-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSTF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSCFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSCFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments NGF TNF Inquiry
MNAB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments NGF TNF Inquiry
MNAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSFC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSFC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSCC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSCC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BIBD-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF TNF Inquiry
BIBD-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF TNF Inquiry
FABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF TNF Inquiry
FABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF TNF Inquiry
MiniB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF TNF Inquiry
MiniB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF TNF Inquiry
SCDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF TNF Inquiry
FABIG-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF TNF Inquiry
TRIB-H346 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body NGF TNF Inquiry
BSIG-H344 Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF TNF Inquiry
CROSSAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab NGF TNF Inquiry
IGFV-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF TNF Inquiry
BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF TNF Inquiry
BSFAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF TNF Inquiry
BSFV-H343 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF TNF Inquiry
SCDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF TNF Inquiry
FABIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF TNF Inquiry
TRIB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body NGF TNF Inquiry
BSIG-182 Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF TNF Inquiry
IGFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF TNF Inquiry
BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF TNF Inquiry
BSFAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF TNF Inquiry
BSFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF TNF Inquiry
BSTF-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSTF-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSTF-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSTF-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSCFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSCFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
MNAB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
MNAB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
MNAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
MNAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSFC-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSFC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSFC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSFC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCC-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSCC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSCC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BIBD-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 TNF Inquiry
BIBD-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin TNF Inquiry
BIBD-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 TNF Inquiry
BIBD-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin TNF Inquiry
FABFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 TNF Inquiry
FABFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin TNF Inquiry
FABFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 TNF Inquiry
FABFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin TNF Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin TNF Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin TNF Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin TNF Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin TNF Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-H195 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body Albumin TNF Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-H193 Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin TNF Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin TNF Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin TNF Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin TNF Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin TNF Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin TNF Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin TNF Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin TNF Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body Albumin TNF Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-007 Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin TNF Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin TNF Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin TNF Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin TNF Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin TNF Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin TNF Inquiry

Background

Tumor Necrosis Factor-alpha (TNF-α) constitutes a multifunctional pro-inflammatory cytokine, primarily synthesized in monocytic and macrophage cells. TNF-α functions within the immune system, where its activation invariably amplifies immunological responses and instigates inflammatory actions.

Meanwhile, the Nerve Growth Factor (NGF) fosters organogenesis by propagating the growth of endocrine or immune system-influenced sympathetic neurons, peripheral sensory neurons, and vasculature. Additionally, NGF plays an integral role in the regulation of insulin secretion, lipolysis, and maintenance of metabolic balance.

Historically, the disparate roles of TNF-α and NGF across varying systems have been examined independently. However, accumulating evidence suggests that NGF holds the capacity to modulate inflammatory phenotypes and cytokine secretion, thereby participating in immune system functionality through a crosstalk mechanism with TNF-α. This interface is postulated to be strongly associated with the pathogenesis of various diseases including asthma, lung cancer, and allergies among others.

Signaling pathways of NGF and TNF-α. (Takei, et al., 208) Fig.1 NGF and TNF-α signaling.1

Reference

  1. Takei, Laskey, et al. " Interpreting crosstalk between TNF-α and NGF: potential implications for disease." Trends in Molecular Medicine. 14.9 (2008): 381.
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