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CD89 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
FABFV-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-Fv) Human Fab-Fv CD89 Mouse EGFR Mouse Inquiry
FABFV-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Mouse CD89 Mouse Inquiry
MiniB-H307 Recombinant Human Anti-CD89 x Human Anti-Malaria Antigen Bispecific Antibody (Minibody) Human Minibody CD89 Human Malaria Antigen Human Inquiry
MiniB-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD89 Human HIV-1 gp41 Human Inquiry
MiniB-H305 Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (Minibody) Human Minibody CD89 Human EGFR Human Inquiry
MiniB-H222 Recombinant Human Anti-CD19 x Human Anti-CD89 Bispecific Antibody (Minibody) Human Minibody CD19 Human CD89 Human Inquiry
MiniB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Minibody) Human Minibody CD89 Mouse S. pneumoniae Mouse Inquiry
MiniB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Minibody) Human Minibody CD89 Mouse Malaria Antigen Mouse Inquiry
MiniB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD89 Mouse HIV-1 gp41 Mouse Inquiry
MiniB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Minibody) Human Minibody CD89 Mouse EGFR Mouse Inquiry
MiniB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Minibody) Human Minibody CD19 Mouse CD89 Mouse Inquiry
SCTB-H195 Recombinant Human Anti-HIV-1 gp41 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody HIV-1 gp41 Human CD89 Human Inquiry
SCTB-H194 Recombinant Human Anti-EGFR x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody EGFR Human CD89 Human Inquiry
SCTB-H120 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Human CD89 Human Inquiry
SCDB-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Human Malaria Antigen Human Inquiry
SCDB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Human HIV-1 gp41 Human Inquiry
SCDB-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Human EGFR Human Inquiry
SCDB-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Human CD89 Human Inquiry
FABIG-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Human Malaria Antigen Human Inquiry
FABIG-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Human HIV-1 gp41 Human Inquiry
FABIG-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Human EGFR Human Inquiry
FABIG-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Human CD89 Human Inquiry
TRIB-H307 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Human Malaria Antigen Human Inquiry
TRIB-H306 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Human HIV-1 gp41 Human Inquiry
TRIB-H305 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Human EGFR Human Inquiry
TRIB-H222 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Human CD89 Human Inquiry
BSIG-H305 Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Human Malaria Antigen Human Inquiry
BSIG-H304 Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Human HIV-1 gp41 Human Inquiry
BSIG-H303 Human Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Human EGFR Human Inquiry
BSIG-H220 Human Anti-CD19 x Anti-CD89 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Human CD89 Human Inquiry
CROSSAB-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (CrossMab) Human CrossMab CD89 Human Malaria Antigen Human Inquiry
CROSSAB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD89 Human HIV-1 gp41 Human Inquiry
CROSSAB-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD89 Human EGFR Human Inquiry
CROSSAB-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (CrossMab) Human CrossMab CD19 Human CD89 Human Inquiry
IGFV-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Human Malaria Antigen Human Inquiry
IGFV-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Human HIV-1 gp41 Human Inquiry
IGFV-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Human EGFR Human Inquiry
IGFV-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Human CD89 Human Inquiry
BSDB-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Diabody) Human Diabody CD89 Human Malaria Antigen Human Inquiry
BSDB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD89 Human HIV-1 gp41 Human Inquiry
BSDB-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD89 Human EGFR Human Inquiry
BSDB-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Diabody) Human Diabody CD19 Human CD89 Human Inquiry
BSFAB-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Human Malaria Antigen Human Inquiry
BSFAB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Human HIV-1 gp41 Human Inquiry
BSFAB-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Human EGFR Human Inquiry
BSFAB-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Human CD89 Human Inquiry
BSFV-H305 Recombinant Human Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Human Malaria Antigen Human Inquiry
BSFV-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Human HIV-1 gp41 Human Inquiry
BSFV-H303 Recombinant Human Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Human EGFR Human Inquiry
BSFV-H220 Recombinant Human Anti-CD19 x Anti-CD89 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Human CD89 Human Inquiry
SCTB-103 Recombinant Anti-S. pneumoniae x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody S. pneumoniae Mouse CD89 Mouse Inquiry
SCTB-102 Recombinant Anti-Malaria Antigen x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody Malaria Antigen Mouse CD89 Mouse Inquiry
SCTB-101 Recombinant Anti-HIV-1 gp41 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody HIV-1 gp41 Mouse CD89 Mouse Inquiry
SCTB-100 Recombinant Anti-EGFR x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody EGFR Mouse CD89 Mouse Inquiry
SCTB-020 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Mouse CD89 Mouse Inquiry
SCDB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Mouse S. pneumoniae Mouse Inquiry
SCDB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Mouse Malaria Antigen Mouse Inquiry
SCDB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Mouse HIV-1 gp41 Mouse Inquiry
SCDB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Mouse EGFR Mouse Inquiry
SCDB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD89 Mouse Inquiry
FABIG-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse S. pneumoniae Mouse Inquiry
FABIG-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse Malaria Antigen Mouse Inquiry
FABIG-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse HIV-1 gp41 Mouse Inquiry
FABIG-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse EGFR Mouse Inquiry
FABIG-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD89 Mouse Inquiry
TRIB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse S. pneumoniae Mouse Inquiry
TRIB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse Malaria Antigen Mouse Inquiry
TRIB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
TRIB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse EGFR Mouse Inquiry
TRIB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD89 Mouse Inquiry
BSIG-135 Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse S. pneumoniae Mouse Inquiry
BSIG-134 Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse Malaria Antigen Mouse Inquiry
BSIG-133 Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSIG-132 Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse EGFR Mouse Inquiry
BSIG-045 Anti-CD19 x Anti-CD89 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD89 Mouse Inquiry
CROSSAB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse S. pneumoniae Mouse Inquiry
CROSSAB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse Malaria Antigen Mouse Inquiry
CROSSAB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse HIV-1 gp41 Mouse Inquiry
CROSSAB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse EGFR Mouse Inquiry
CROSSAB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD89 Mouse Inquiry
IGFV-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse S. pneumoniae Mouse Inquiry
IGFV-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse Malaria Antigen Mouse Inquiry
IGFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
IGFV-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse EGFR Mouse Inquiry
IGFV-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD89 Mouse Inquiry
BSDB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Diabody) Human Diabody CD89 Mouse S. pneumoniae Mouse Inquiry
BSDB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Diabody) Human Diabody CD89 Mouse Malaria Antigen Mouse Inquiry
BSDB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSDB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD89 Mouse EGFR Mouse Inquiry
BSDB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD89 Mouse Inquiry
BSFAB-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse S. pneumoniae Mouse Inquiry
BSFAB-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse Malaria Antigen Mouse Inquiry
BSFAB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSFAB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse EGFR Mouse Inquiry
BSFAB-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD89 Mouse Inquiry
BSFV-135 Recombinant Anti-CD89 x Anti-S. pneumoniae Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse S. pneumoniae Mouse Inquiry
BSFV-134 Recombinant Anti-CD89 x Anti-Malaria Antigen Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse Malaria Antigen Mouse Inquiry
BSFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSFV-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse EGFR Mouse Inquiry
BSFV-045 Recombinant Anti-CD19 x Anti-CD89 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD89 Mouse Inquiry

Background

CD89 has been discovered on many myeloid cells and belongs to the FcR immunoglobulin class. CD89 is a type of transmembrane glycoprotein that can bind to all molecular forms of both subclasses of IgA. When CD89 is bound together by IgA immune complexes or IgA-opsonized pathogens, neutrophils exhibit increased phagocytosis and production of reactive oxygen species (ROS), cytokines, etc. Furthermore, CD89 is a significant innate receptor capable of independently binding bacteria, regardless of its corresponding ligands. According to the available evidence, CD89 on Kupffer cells forms an immune "secondary barrier of defense" in the mucosa by interacting with serum IgA. This defense mechanism aids in the elimination of invading germs that enter through the portal circulation.

Fig.1 The function of CD89 in host defense. (de Tymowski, et al., 2019) Fig.1 The function of CD89 in host defense.1

Reference

  1. de Tymowski, Christian, et al. "CD89 is a potent innate receptor for bacteria and mediates host protection from sepsis." Cell Reports 27.3 (2019): 762-775.
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