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FAP Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSDG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG DR5 Mouse FAP Mouse Inquiry
BSDG-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse FAP Mouse Inquiry
BABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Human FAP Human Inquiry
BABFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human FAP Human Inquiry
BABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Mouse FAP Mouse Inquiry
BABFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse FAP Mouse Inquiry
FABVC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Human FAP Human Inquiry
FABVC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human FAP Human Inquiry
FABVC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Mouse FAP Mouse Inquiry
FABVC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse FAP Mouse Inquiry
SCDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Human FAP Human Inquiry
SCDBC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human FAP Human Inquiry
SCDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Mouse FAP Mouse Inquiry
SCDBC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse FAP Mouse Inquiry
BSDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Human FAP Human Inquiry
BSDBC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human FAP Human Inquiry
BSDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Mouse FAP Mouse Inquiry
BSDBC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse FAP Mouse Inquiry
SCDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Human FAP Human Inquiry
SCDBF-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human FAP Human Inquiry
SCDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Mouse FAP Mouse Inquiry
SCDBF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse FAP Mouse Inquiry
BSFVF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Human FAP Human Inquiry
BSFVF-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human FAP Human Inquiry
BSFVF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSFVF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse FAP Mouse Inquiry
BSDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Human FAP Human Inquiry
BSDBF-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human FAP Human Inquiry
BSDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Mouse FAP Mouse Inquiry
BSDBF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse FAP Mouse Inquiry
BSTF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSTF-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse FAP Mouse Inquiry
BSTF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSTF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse FAP Mouse Inquiry
BSCFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSCFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FAP Mouse Inquiry
BSCFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSCFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FAP Mouse Inquiry
MNAB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
MNAB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FAP Mouse Inquiry
MNAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
MNAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FAP Mouse Inquiry
BSFC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSFC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FAP Mouse Inquiry
BSFC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSFC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FAP Mouse Inquiry
BSCC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BSCC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FAP Mouse Inquiry
BSCC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BSCC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FAP Mouse Inquiry
BIBD-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
BIBD-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FAP Mouse Inquiry
BIBD-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
BIBD-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FAP Mouse Inquiry
FABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Human FAP Human Inquiry
FABFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human FAP Human Inquiry
FABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Mouse FAP Mouse Inquiry
FABFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse FAP Mouse Inquiry
MiniB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Human FAP Human Inquiry
MiniB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 Human FAP Human Inquiry
MiniB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Mouse FAP Mouse Inquiry
MiniB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 Mouse FAP Mouse Inquiry
SCTB-H151 Recombinant Human Anti-FAP x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human FAP Human Inquiry
SCDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Human FAP Human Inquiry
SCDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human FAP Human Inquiry
FABIG-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Human FAP Human Inquiry
FABIG-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human FAP Human Inquiry
TRIB-H320 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Human FAP Human Inquiry
TRIB-H256 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human FAP Human Inquiry
BSIG-H318 Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Human FAP Human Inquiry
BSIG-H254 Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human FAP Human Inquiry
CROSSAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Human FAP Human Inquiry
CROSSAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Human FAP Human Inquiry
IGFV-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Human FAP Human Inquiry
IGFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human FAP Human Inquiry
BSDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Human FAP Human Inquiry
BSDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 Human FAP Human Inquiry
BSFAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Human FAP Human Inquiry
BSFAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human FAP Human Inquiry
BSFV-H317 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Human FAP Human Inquiry
BSFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human FAP Human Inquiry
SCTB-053 Recombinant Anti-FAP x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse FAP Mouse Inquiry
SCDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Mouse FAP Mouse Inquiry
SCDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse FAP Mouse Inquiry
FABIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Mouse FAP Mouse Inquiry
FABIG-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse FAP Mouse Inquiry
TRIB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Mouse FAP Mouse Inquiry
TRIB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse FAP Mouse Inquiry
BSIG-152 Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Mouse FAP Mouse Inquiry
BSIG-080 Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse FAP Mouse Inquiry
CROSSAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Mouse FAP Mouse Inquiry
CROSSAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse FAP Mouse Inquiry
IGFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Mouse FAP Mouse Inquiry
IGFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse FAP Mouse Inquiry
BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Mouse FAP Mouse Inquiry
BSDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 Mouse FAP Mouse Inquiry
BSFAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Mouse FAP Mouse Inquiry
BSFAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse FAP Mouse Inquiry
BSFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Mouse FAP Mouse Inquiry
BSFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse FAP Mouse Inquiry

Background

Fibroblast Activation Protein-α (FAP) is a transmembrane serine protease, predominantly expressed within pathological circumstances such as epithelial carcinoma, granulomatous tissue, and soft tissue sarcomas. Whilst concrete biological reasons remain somewhat elusive, a notable association has been identified between FAP expression levels and the severity of various cancer types.

FAP concomitantly possesses endopeptidase and dipeptidyl peptidase activity, capable of cleaving α2-antiplasmin, thus transforming it into a more potently effective plasminogen activator inhibitor, subsequently enhancing coagulation effects. Further research has offered compelling evidence that FAP demonstrates functions beyond enzyme activity, with wide-ranging biological impacts that encompass immunosuppression, epithelial-to-mesenchymal transition, cellular signaling regulation, angiogenesis, and extracellular matrix remodeling.

FAP protein. (Fitzgerald, et al., 2020) Fig.1 FAP protein.1

Reference

  1. Fitzgerald, Weiner, et al. " The role of fibroblast activation protein in health and malignancy." Cancer Metastasis. 39 3 (2020): 783-803.
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