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FIXa Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H327 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FIXa Human FX Human Inquiry
T-BSDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FIXa Mouse FX Mouse Inquiry
KN-1022-LN5 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Common light chain) (BsIgG) Human BsIgG FIXa Human FX Human Inquiry
SCIGG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scIgG) Human Single chain IgGs FIXa Human FX Human Inquiry
SCIGG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scIgG) Human Single chain IgGs FIXa Mouse FX Mouse Inquiry
BSAB-001 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (KIH-IgG) Human KIH-IgG FIXa Human FX Human Inquiry
FVTIG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FIXa Human FX Human Inquiry
FVTIG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FIXa Mouse FX Mouse Inquiry
BSSG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-IgG) Human scFv-IgG FIXa Human FX Human Inquiry
BSSG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-IgG) Human scFv-IgG FIXa Mouse FX Mouse Inquiry
IGLFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FIXa Human FX Human Inquiry
IGLFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FIXa Mouse FX Mouse Inquiry
BSGV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (IgG-Fv) Human IgG-Fv FIXa Mouse FX Mouse Inquiry
BSGV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG-Fv) Human IgG-Fv FIXa Mouse FX Mouse Inquiry
BSDG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fv-IgG) Human Fv-IgG FIXa Human FX Human Inquiry
BSDG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fv-IgG) Human Fv-IgG FIXa Mouse FX Mouse Inquiry
BABFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FIXa Human FX Human Inquiry
BABFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FIXa Mouse FX Mouse Inquiry
FABVC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FIXa Human FX Human Inquiry
FABVC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FIXa Mouse FX Mouse Inquiry
SCDBC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FIXa Human FX Human Inquiry
SCDBC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FIXa Mouse FX Mouse Inquiry
BSDBC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FIXa Human FX Human Inquiry
BSDBC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FIXa Mouse FX Mouse Inquiry
SCDBF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FIXa Human FX Human Inquiry
SCDBF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FIXa Mouse FX Mouse Inquiry
BSFVF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FIXa Human FX Human Inquiry
BSFVF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FIXa Mouse FX Mouse Inquiry
BSDBF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FIXa Human FX Human Inquiry
BSDBF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FIXa Mouse FX Mouse Inquiry
BSTF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FIXa Mouse FX Mouse Inquiry
BSTF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FIXa Mouse FX Mouse Inquiry
BSCFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-Fc) Human scFv-Fc FIXa Mouse FX Mouse Inquiry
BSCFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-Fc) Human scFv-Fc FIXa Mouse FX Mouse Inquiry
MNAB-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Miniantibody) Human Miniantibody FIXa Mouse FX Mouse Inquiry
MNAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Miniantibody) Human Miniantibody FIXa Mouse FX Mouse Inquiry
BSFC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-CH3) Human scFv-CH3 FIXa Mouse FX Mouse Inquiry
BSFC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-CH3) Human scFv-CH3 FIXa Mouse FX Mouse Inquiry
BSCC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FIXa Mouse FX Mouse Inquiry
BSCC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FIXa Mouse FX Mouse Inquiry
BIBD-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Bibody) Human Bibody FIXa Mouse FX Mouse Inquiry
BIBD-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Bibody) Human Bibody FIXa Mouse FX Mouse Inquiry
FABFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fab-Fv) Human Fab-Fv FIXa Human FX Human Inquiry
FABFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-Fv) Human Fab-Fv FIXa Mouse FX Mouse Inquiry
MiniB-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Minibody) Human Minibody FIXa Human FX Human Inquiry
MiniB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Minibody) Human Minibody FIXa Mouse FX Mouse Inquiry
SCDB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FIXa Human FX Human Inquiry
FABIG-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Fab-IgG) Human Fab-IgG FIXa Human FX Human Inquiry
TRIB-H329 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FIXa Human FX Human Inquiry
BSIG-H327 Human Anti-FIXa x Anti-FX Bispecific Antibody (IgG-IgG) Human IgG-IgG FIXa Human FX Human Inquiry
CROSSAB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (CrossMab) Human CrossMab FIXa Human FX Human Inquiry
IGFV-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (IgG-scFv) Human IgG-scFv FIXa Human FX Human Inquiry
BSDB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Diabody) Human Diabody FIXa Human FX Human Inquiry
BSFAB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Fab) Human Tandem Fab FIXa Human FX Human Inquiry
BSFV-H325 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv) Human Tandem scFv FIXa Human FX Human Inquiry
SCDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FIXa Mouse FX Mouse Inquiry
FABIG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-IgG) Human Fab-IgG FIXa Mouse FX Mouse Inquiry
TRIB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FIXa Mouse FX Mouse Inquiry
BSIG-162 Anti-FIXa x Anti-FX Bispecific Antibody (IgG-IgG) Human IgG-IgG FIXa Mouse FX Mouse Inquiry
CROSSAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (CrossMab) Human CrossMab FIXa Mouse FX Mouse Inquiry
IGFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG-scFv) Human IgG-scFv FIXa Mouse FX Mouse Inquiry
BSDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody) Human Diabody FIXa Mouse FX Mouse Inquiry
BSFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv) Human Tandem scFv FIXa Mouse FX Mouse Inquiry
BSFAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Fab) Human Tandem Fab FIXa Mouse FX Mouse Inquiry

Background

Coagulation factor X (FIX) is synthesized by liver cells as a precursor to the serine protease FIXa and is a vitamin K-dependent protein. FIXa, a thrombotic trigger after infusion of prothrombin complex concentrate, is initially seen as a protein specifically responsible for thrombosis, and it also plays a major role in platelet-mediated hemostasis. Thrombin may activate FXI on the surface of platelets to FXIa through a feedback mechanism, thereby activating FIX to FXa, achieving sustained and consolidated coagulation. A variety of approaches are available to target FIXa activity, including monoclonal antibodies, RNA aptamers, oral inhibitors, and synthetic active site-blocking competitive inhibitors. Monoclonal antibodies have infiltrated the anticoagulant scene, as multiple antibodies directed against the Gla domain of FIX have been investigated. Most FIX/FIXa inhibitors evaluated in preclinical models have been designed to block protein-protein or other macromolecular interactions, such as monoclonal antibodies against the FIX-FIXa Gla domain that block binding of FIX-FIXa to cell surfaces, or nucleic acid aptamers, which block the interaction of FX with the FIXa-FVIIIa complex.

Fig.1 Schematic illustration for the idea of anti-FIXa/FX bispecific antibody with a FVIIIa-cofactor activity. (Kitazawa, 2020) Fig.1 Schematic illustration for the idea of anti-FIXa/FX bispecific antibody with a FVIIIa-cofactor activity.1

Reference

  1. Kitazawa, Takehisa, and Midori Shima. "Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity." International Journal of Hematology 111 (2020): 20-30.
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