Home > Products > CEA & GD2 > Recombinant Anti-CEA x Anti-GD2 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-CEA x Anti-GD2 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin)  (BSFAB-NGB005)

Recombinant Anti-CEA x Anti-GD2 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Nigrin b (NGB) fused to a tandem Fab recognizing CEA and GD2. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver NGB to antigen-specific cells. Then NGB is a lectin and can kill the target cells. The bispecific immunotoxin is designed for the research of Neuroblastoma; Osteosarcoma; Melanoma; Solid tumors therapy.

Specifications

Targets
CEA & GD2
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
GD2
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Neuroblastoma; Osteosarcoma; Melanoma; Solid tumors

Targets

Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
GD2
Alternative Names
Ganglioside GD2; GD2; Ganglioside; Disialoganglioside GD2

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