Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Bouganin (BGN) fused to a tandem Fab recognizing HER3 and IGF1R. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver BGN to antigen-specific cells. Then BGN is a single chain, type I ribosone inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Pancreatic cancer; Hepatocellular carcinoma (HCC) therapy.
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