Anti-Angiopoietin-2 Aptamer(Cat#: CTApt-M-038)

This product is an aptamer which binds to the ANGPT2 with an affinity of <20 nM.

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Specifications
Target Category Protein
Target ANGPT2
Alternative Names Angiopoietin 2; Angiopoietin-2 ; Ang2 ; Angiopoietin-2B ; Angiopoietin-2a ; Tie2-Ligand ; LMPHM10 ; AGPT2 ; ANG-2 ; ANG2A
Gene ID 285
UniProt ID P40763
Target Overview This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome.
Chemical Modification RNA
Length 40-60 nt
Affinity (Kd) <20 nM
Binding Conditions/Buffer 20 mM Hepes, pH 7.4, 150 mM NaCl, 2 mM
CaCl2, 0.01% BSA.
GC Content 0.61
Molecular Weight 12434.9
nmoles/OD260 2.321

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