This is an aptamer development services to screening aptamers binds to the ANGPT2 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | ANGPT2 |
| Alternative Names | Angiopoietin 2; Angiopoietin-2; ANG-2; Angiopoietin-2B; Angiopoietin-2a; Tie2-Ligand; ANGPT2; AGPT2; ANG2; Ang2 |
| Gene ID | 285 |
| UniProt ID | O15123 |
| Target Overview | This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |