Mouse Anti-Human CD11c Monoclonal Antibody (CTJS-8)(Cat#: CTA-221)
This product is an unconjugated anti-Human CD11c Monoclonal antibody (CTJS-8) generated from the Mouse. The antibody can be used for WB; FC; IHC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-8 |
| Host Animal |
Mouse |
| Isotype |
IgG1 Kappa |
| Immunogen |
Hairy cell leukaemia cells |
| Species Reactivity |
Human |
| Applications |
WB; FC; IHC |
| Application Notes |
WB: 1:100 - 1:2000
FC: 1:10 - 1:1000
IHC: 1:10 - 1:500
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human CD11c. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
25; 100 µL |
| Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
CD11c |
| Alternative Names |
Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c |
| Gene ID |
3687 |
| UniProt ID |
P20702 |
Information
| Introduction |
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
