Armenian Hamster Anti-Mouse CD11c Monoclonal Antibody (CTJS-77)(Cat#: CTA-210)

This product is an unconjugated anti-Mouse CD11c Monoclonal antibody (CTJS-77) generated from the Armenian Hamster. The antibody can be used for FC; IF; IHC; IP; .

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Specifications
Clonality Monoclonal
Clone CTJS-77
Host Animal Armenian Hamster
Isotype IgG
Immunogen This CD11c antibody was produced from a hybridoma (mouse myeloma fused with spleen cells)from an Armenian Hamster immunized with mouse lymphocytes.
Species Reactivity Mouse
Applications FC; IF; IHC; IP;
Application Notes FC: 1:100-1:1000
IHC: 1:25-1:100
IP: 1:10-1:500
The optimal working dilutions should be determined by the end user.
Specificity This antibody reacts with Mouse CD11c.
Purity ≥95% as determined by SDS-PAGE
Format Lyophilized
Size 100 µg
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Type Primary Antibody
Target
Target Name CD11c
Alternative Names Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c
Gene ID 3687
UniProt ID P20702
Information
Introduction CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

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