Creative Biolabs is dedicated to delivering the highest quality models and related services. Our staff are highly specialized and will work closely with you from the selection of proper models, study plan design to final data analysis and reporting. For rheumatoid arthritis studies, we provide CIA, AIA, and CAIA models.
Features of Collagen Induced Arthritis (CIA) Model
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Of the various animal models of rheumatoid arthritis (RA), collagen induced arthritis (CIA) is the most widely studied and used standard model, largely on the basis of the preclinical, pathological and immunological similarities between CIA and RA. Creative Biolabs offers CIA models elicited in genetically susceptible strains of both rats and mice by immunization with heterologous (usually bovine, chick, or rat) or autologous type II collagen emulsified in the adjuvant, resulting in different forms of arthritis (acute or protracted).
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Fig.1 Clinical signs of CIA in the hind paws of femaleThe pathological features CIA model shared with RA include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, cartilage destruction, bone resorption, pannus formation and fibrosis. Additionally, susceptibility to both CIA and RA is linked with genes encoding MHC class II molecules, which indicates the role of CD4+ T cells in these two diseases. What's more, similar to RA in humans, CIA models abundantly express proinflammatory cytokines, involving tumor necrosis factor (TNFα) and interleukin (IL)-1β.
Creative Biolabs is capable of offering various assessments, including but not limited to:
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Fig.2 Clinical progression of CIA in female Wistar rats during a 30-day course
(A) Arthritic score, (B) hind paw volume, (C) body weight and (D) ESR.
(Song et al. 2014)
Application of Collagen Induced Arthritis (CIA) Model
The CIA model has been applied to elucidate underlying pathogenic mechanisms of rheumatoid arthritis disease, involving the role of individual cell types in disease onset and progression, as well as to design and test new therapeutics. Recently, the CIA model has played an important role in the testing and development of the new biologically based therapeutics, such as those that target TNFα, a cytokine produced by macrophages and T cells and is a dominant inflammatory mediator in the pathogenesis of RA.
Meanwhile, in order to meet our customers' specific requirements and their various research objectives, Creative Biolabs also offers other rodent inflammatory & immunological disease models listed as follows that you may be interested in:
With years of experience, our scientists understand that the right research models give you the foundation for consistent study data. At Creative Biolabs, you will find pleasing services of designing, conducting and analyzing animal efficacy studies for your drug candidates. Contact us to get your project underway.
Reference
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