Rodent Inflammation & Immunological Disease Modeling & Pharmacodynamics Services

Creative Biolabs offers a wide range of pre-clinical services that enable customers to screen potential efficient drug candidates as well as identify novel therapeutic targets in relevant animal models of human diseases. Our scientists and specialists have extensive experience in assisting our customers with the selection of appropriate models and assays, as well as working together to develop new animal models tailored to meet the specific needs of a particular tested item or discovery program.

Available Models

Existing well-characterized models of inflammation, as well as immunological disease provided by Creative Biolabs, involve skin inflammation, gastrointestinal inflammation, joint inflammation, respiratory diseases, sepsis, EAE, systemic lupus erythematosus disease and so on. Each model is coupled with measurements of different parameters that can be used to evaluate the efficacy of candidate drugs in the preclinical phase. A well-trained group of scientists will be assigned to your project, working closely with you from the initial experimental design to final data analysis, to ensure the most relevant and reliable results can be achieved.

Learn more about the different models of inflammatory and immunological diseases Creative Biolabs offers for preclinical research by clicking on the links below:

Systemic Inflammation Models

• Carrageenan Air Pouch Model
• Carrageenan-Induced Paw Edema Model
• Mouse Auricle Swelling Inflammatory Model
• Acetic Acid-Induced Mouse Vascular Permeability Model
• Testosterone-Induced Benign Prostatic Hyperplasia Model

Inflammatory Bowel Disease (IBD) Models

• TNBS/DNBS-Induced Rodent Colitis Model
• DSS-Induced Rodent Colitis Model
• Indomethacin-Induced Rodent Inflammation in Small Intestine
• OXA-Induced Rodent Colitis Model
• CD4⁺CD45RB^high T cells induced Inflammatory Bowel Disease (IBD) Model

Rheumatoid Arthritis (RA) Models

• Adjuvant-Induced Arthritis (AIA) Rodent Model
• Collagen-Induced Arthritis Rodent Model
• Collagen Antibody-Induced Arthritis (CAIA) Model
• Antigen-Induced Arthritis Model

Experimental Autoimmune Encephalomyelitis (EAE) Models

• MOG35-55-Induced EAE Mice Model
• PLP-Induced EAE Mice Model
• MBP-Induced EAE Rat Model

Systemic Lupus Erythematosus (SLE) Models

• Spontaneous Systemic Lupus Erythematosus (SLE) Mouse models
• Induced Models of Systemic Lupus Erythematosus

Psoriasis Models

• Imiquimod (IMQ)-Induced Psoriasis Rodent Models
• IL-23-Induced Psoriasis Mouse Model
• Diethylstilbestrol-Induced Mouse Vaginal Epithelial Mitosis Model
• The Mouse Tail Model of Psoriasis

Peritonitis Models

• Monosodium Urate (MSU) Induced Peritonitis Model
• Zymosan-Induced Peritonitis Model

Atopic Dermatitis and Eczema Models

• Dinitrofluorobenzene (DNFB)-Induced Atopic Dermatitis Model
• House Dust Mite (HDM)-Induced Atopic Dermatitis Model
• Oxazolone (OXZ)-Induced Atopic Dermatitis Model
• Ovalbumin (OVA)-Induced Atopic Dermatitis Model

Sepsis Models

• LPS-Induced Rodent Sepsis Model
• Cecum Ligation and Puncture (CLP)-Induced Sepsis Model
• 2-HIT Sepsis Model
• Escherichia Coli-Induced Sepsis Mice Models

Experimental Sjögren’s Syndrome (ESS) Models

• Submandibular Gland (SG) Protein-Induced Sjogren's Syndrome Mice Model

Gouty Arthritis (GA) Models

• Monosodium Urate-Induced Air-Pouch Model of Gouty Arthritis in Rats
• Monosodium Urate-Induced Gouty Arthritis in Rats

GVHD Models

• Graft Versus Host Disease (GVHD) Model

Asthma Models

• Ovalbumin-Induced Asthma Model
• HDM-Induced Allergic Asthma Model

Osteoarthritis Models (OA)

• Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model
• Surgically-Induced Osteoarthritis (OA) Models

Delayed Type Hypersensitivity (DTH) Rodent Models

• Chemical-Induced Rodent Contact Hypersensitivity Models

Passive Cutaneous Anaphylaxis (PCA) Models

• Passive Cutaneous Anaphylaxis (PCA) Models

Experimental Autoimmune Neuritis (EAN) Models

• P0180-199 Peptide-Induced Experimental Autoimmune Neuritis Rat Model

Ocular Inflammation Models

• Endotoxin-Induced Uveitis Rat Model
• IRBP-Induced EAU Rat Model

Measurements

We offer various measurements for drug efficacy studies and screening using a wide range of technologies, including but not limited to:

• General observations (e.g., body weight, mortality rate, stool consistence, occult bleeding).
• Measurement of joint swelling, ear thickness, skin thickness, colon length, and lung weight.
• Cytokine profiling and inflammatory cell infiltration.
• Pain assessment.
• Hematology analysis and serum biomarkers (e.g., alkaline phosphatase, albumin).
• Histological, immunohistochemical, and morphological analysis.
• Gene/protein expression profile using RT qPCR and Western-blot.

In addition to the well-established models listed above, our expertise in the new animal model development and model validation from the literature where models can be tailored to a specific project is another strength. Our scientific group will not only assist you in the project design and model selection but also in data analysis. Personalized support will help to inform how the project progresses at every stage of the process, from before the project initiates to after the model is successfully delivered.

Creative Biolabs is happy to share our cutting-edge technology and extensive expertise in rodent disease models to facilitate our clients’ research and project development. Please feel free to inquire us for more detailed information if you are interested in any of these models. In case you do not see the models that you are interested in, please contact us and we’ll be in touch within 24 hours to let you know if it is feasible.

Products

Case Study

You can find the most appropriate model to evaluate the efficacy of your drug candidate.

Inflammatory & Immunological Disease Models in Creative Biolabs.pdf

For Research Use Only.