Rodent Inflammation & Immunological Disease Models

Creative Biolabs offers a wide range of pre-clinical services that enable customers to screen potential efficient drug candidates as well as identify novel therapeutic targets in relevant animal models of human diseases. Our scientists and specialists have extensive experience in assisting our customers with the selection of appropriate models and assays, as well as working together to develop new animal models tailored to meet the specific needs of a particular tested item or discovery program.

Existing well-characterized models of inflammation and immunological disease provided by Creative Biolabs involve skin inflammation, gastrointestinal inflammation, joint inflammation, respiratory diseases, sepsis, EAE, systemic lupus erythematosus disease and so on. Each model is coupled with measurements of different parameters that can be used to evaluate the efficacy of candidate drugs in the preclinical phase. A well-trained group of scientists will be assigned to your project, working closely with you from the initial experimental design to final data analysis, to ensure the most relevant and reliable results can be achieved.

Learn more about the different models of inflammatory and immunological diseases for preclinical research by clicking on the links below:

Acute Inflammation

• Carrageenan Air Pouch Model
• Carrageenan-Induced Paw Edema Model

Dermal Inflammation

• Chemical-Induced Rodent Contact Hypersensitivity Model
• Imiquimod (IMQ)-Induced Psoriasis Rodent Model
• Passive Cutaneous Anaphylaxis (PCA) Model
• Delayed Type Hypersensitivity (DTH) Rodent Model

Rheumatoid Arthritis

• Adjuvant-Induced Arthritis (AIA) Rodent Model
• Collagen-Induced Arthritis (CIA) Rodent Model
• Collagen Antibody-Induced Arthritis (CAIA) Model

Sepsis

• Cecum Ligation and Puncture (CLP)-Induced Sepsis Model
• LPS-Induced Rodent Sepsis Model
• 2-HIT Model of Sepsis

Systemic Lupus Erythematosus (SLE)

• Spontaneous Systemic Lupus Erythematosus (SLE) Mouse Models
• Induced Models of Systemic Lupus Erythematosus

In addition to the well-established models listed above, our expertise in the new animal model development and model validation from the literature where models can be tailored to a specific project is another strength. Our scientific group will not only assist you in the project design and model selection but also in data analysis. Personalized support will help to inform how the project progresses at every stage of the process, from before the project initiates to after the model is successfully delivered.

Creative Biolabs is happy to share our cutting-edge technology and extensive expertise in rodent disease models to facilitate our clients' research and project development. Please feel free to inquire us for more detailed information if you are interested in any of these models. In case you do not see the models that you are interested in, please contact us and we'll be in touch within 24 hours to let you know if it is feasible.

Reference

1. Hoogenboom, H.R., 2005. Selecting and screening recombinant antibody libraries. Nature biotechnology, 23(9), pp.1105-1116.

For Research Use Only.