Creative Biolabs has plenty of experience in Rheumatoid Arthritis research and our team will work closely with you from the selection of proper models, study plan design to final data analysis and reporting. Creative Biolabs provides clients across the globe with the most comprehensive preclinical animal testing services for Rheumatoid Arthritis, which include developing validated animal models of Rheumatoid Arthritis, evaluating drug candidates' toxicity and efficacy in rodents and so on.
-Rodent-Model-1.png)
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Animal models of RA have proven to be useful tools for preclinical research as well as for the study of pathogenesis due to the fact that animal models can mimic various aspects of RA in humans.
Application of Adjuvant-Induced Arthritis (AIA) Model
Among the established animal models of RA, adjuvant-induced arthritis (AIA) model is one of the most commonly used standard arthritis models, reflecting a number of clinical characteristics of RA in humans, including inflammation with swelling of the joints, proliferation of synovial tissue, and destruction of cartilage and bone. It is because of the finding that certain strains of rats develop arthritis after administration of complete Freund's adjuvant (CFA) that the model was initially established. Since then it has been successfully applied in preclinical research for evaluation of antirheumatic drugs and toxicity prediction. Indicators such as paw thickness, clinical score, body, weight, histopathology, pain assessments and X-radiography lay the foundation for evaluation of these drugs.
-Rodent-Model-2.png)
Fig.1 Anti-inflammatory effect of UP1304 as measured by ankle diameter in adjuvant-induced arthritis. (Yimam et al. 2016)
Features of Adjuvant-Induced Arthritis (AIA) Model
Although the mechanism underlying induction of AIA is not completely characterized, the fact that susceptibility is linked to certain MHC class alleles and that antibodies to CD4 and MHC class II molecules can inhibit disease confirms the importance of CD4+. A difference between AIA and CIA is that AIA is induced by substances that do not contain a defined self-antigen. Additionally, AIA model generally shows less severe symptoms and is transient. A difference between AIA and RA is that AIA exhibits quite a rapid remission while human RA continues for a long time.
Creative Biolabs is capable of offering various assessments, which include but not limited to:
Meanwhile, in order to meet our customers' specific requirements and their various research objectives, Creative Biolabs also offers other rodent inflammatory & immunological disease models listed as follows that you might be interested in:
Creative Biolabs has a group of scientists with deep therapeutic expertise and years of experience in the field of model development and validation. We promise to provide our clients with the most reliable services at the most favorable prices. Contact us or send us an inquiry to maximize the value of your next project and beyond.
Reference
For Research Use Only.
