With fully-equipped facilities, a professional R&D team, and a standardized management system, Creative Biolabs is a professional CRO company recognized by our global clients. We provide well-established non-human primate (NHP) disease models involving multiple system diseases (please click here to find more information). Also, we have assisted our clients with their preclinical non-GLP projects on our pharmacology and pharmacodynamics (PD/PK) platform.
Myocardial fibrosis is a pathological process characterized by the excessive deposition of collagen components in the interstitium of the myocardium with changes in the proportion and spatial position of collagens. Different stimuli may trigger myocardial fibrosis, including pressure overload, immune damage, ischemia, and high glucose. Myocardial fibrosis can lead to increased myocardial stiffness, decreased ventricular diastolic function, decreased coronary blood flow reserve, severe ventricular arrhythmia, and even sudden death.
Animal models are powerful tools for preclinical research. Existing animal models of myocardial fibrosis are as follows: the pressure overload-induced model (the modeling methods include spontaneous hypertension induction, two-kidney one-clamp method, abdominal aortic constriction method, angiotensin II induction, and aldosterone induction); the immune injury-induced model (the modeling methods include myocardial autoantigens induction, cardiomyosin epitopes induction, myocardial protein C epitopes induction, autoimmune CD4+ T cells induction, and activated dendritic cells induction); the ischemia-induced model (the modeling methods include coronary artery ligation induction, isoproterenol or vasopressin induction, spontaneous necrosis, and high glucose induction).
It is of great significance to investigate the pathogenesis, pathological characteristics, diagnosis, and potential therapies of myocardial fibrosis. In order to achieve the above scientific research goals, appropriate preclinical animal models are essential. Choosing a myocardial fibrosis model built on a human-like animal model (such as NHPs) is essential to evaluate the safety of drugs and the immunogenicity of emerging cell therapies. NHPs are not only close to humans in terms of anatomy, physiology, biochemistry, and genetics, but they are also very similar in phylogeny. Therefore, NHPs are a promising species for establishing the myocardial fibrosis model in preclinical research.
Fig.1 Masson's trichrome staining (a) and fibrosis index map (b) of a rhesus monkey of myocardial fibrosis. (Zhang, et al., 2019)
Creative Biolabs has accumulated many years of experience in NHP disease models and collected a lot of scientific data regarding these models. To better assist the myocardial fibrosis research, we provide the well-established NHP model of myocardial fibrosis and related analysis services including but not limited to collagen quantification, stiffness measurement, immunoblot analysis, macrophage immunohistochemistry, FACS, histopathological analysis, Western Blotting, and ELISA.
If you are interested in the NHP model of myocardial fibrosis or have any questions about this model, please feel free to contact us for more information. The scientists of Creative Biolabs are willing to work with you and assist you in your preclinical research. We are your trustworthy CRO partner.
Creative Biolabs offers various Cardiovascular Disease Models you may be interested in:
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