The non-human primate (NHP) disease models of Creative Biolabs have been verified in many experiments and adopted by our global clients to achieve their study goals. As a professional CRO company, we provide a one-stop solution from study design and project execution to data analysis. Based on our pharmacology and pharmacodynamics (PD/PK) platform, we are dedicating to facilitating the development of novel therapeutics.
AMI is myocardial necrosis caused by acute and persistent ischemia and hypoxia of coronary arteries. Common triggers of AMI include overwork, agitation, overeating, cold stimulation, constipation, smoking, heavy drinking, etc. Clinically, patients with AMI often present with severe and long-lasting retrosternal pain which cannot be completely relieved by rest and nitrate drugs. This disease is usually accompanied by increased serum myocardial enzyme activity and progressive changes in the electrocardiogram, and it can be complicated by arrhythmia, shock, or heart failure, which is often life-threatening.
As it is difficult to obtain many pathophysiological data on AMI from clinical research, progress in the prevention and treatment of AMI relies on breakthroughs in preclinical research. Therefore, establishing an appropriate animal model of AMI is essential. The AMI model has great value in studying the pathophysiological and electrophysiological changes of human AMI as well as evaluating various treatment methods. Animals that are currently used to establish AMI include small animals (such as rats and mice) and large animals (such as dogs, pigs, sheep, and NHPs). The most frequently used animal AMI model is based on left anterior descending coronary artery ligation.
A comprehensive understanding of the relationship between infarct size and cardiac reserve is of great significance for improving cardiac function after AMI. However, due to safety concerns, it is not feasible to perform such tests on patients. Accordingly, animal models of AMI are considered as an essential tool. Rodents are currently the most widely used experimental species, whereas the NHP model is the ideal one for human research on AMI since NHPs have a high degree of similarity with humans in terms of coronary artery distribution and other cardiac physiology.
Fig.1 Infraction size of rhesus monkey of acute myocardial infarction (AMI) models after administration of different treatments. (Zeng, et al., 2016)
With much experience in the NHP disease model establishment, Creative Biolabs provides the well-established NHP model of AMI. We offer cardiac functional measurements and histology including H&E staining, TTC staining, and Masson staining for the evaluation of drug efficacy. In the meantime, biomarkers analysis by immunochemistry, quantitative PCR, Western Blot, and transmission electron microscopy assay deepen the understanding of AMI pathogenesis and the action of potential therapeutics in vivo.
If you are interested in the NHP model of AMI or have any questions about this model, please feel free to contact us for more information. The scientists of Creative Biolabs will work closely with you and provide scientific solutions to advance your study project. We are your trustworthy CRO partner.
Creative Biolabs offers various Cardiovascular Disease Models you may be interested in:
Reference
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