With fully-equipped facilities, a professional R&D team, and the most stringent Q&C system, Creative Biolabs has provided professional CRO services for many years. Creative Biolabs is recognized as a trustworthy CRO company by our clients all over the world. Our pharmacology and pharmacodynamics platform acts as a model bank that covers a wide range of indications and allows the evaluation of new therapeutics in both rodents and primates.
Venous thrombosis, referring to the abnormal coagulation of blood in the vein, can be caused by slow blood flow, damage to the vein wall, and a hypercoagulable state. After thrombosis, except for a few thrombi that can ablate on their own or are confined to the site of occurrence, most of the thrombi will spread to the deep vein trunk of the entire limb. If thrombosis is not diagnosed and treated in time, fatal pulmonary embolism is likely to occur.
Through thrombosis models, researchers have confirmed a variety of factors that can induce thrombosis and accumulated a lot of scientific data on the pathological development of thrombosis. Also, the efficacy of various potential therapeutics has been evaluated. At present, rodents (rats and mice), rabbits, and NHPs have been adopted as tools to establish the preclinical thrombosis models. The present thrombosis models include the stasis model, the St. Thomas model, the stenosis model, the electrolytic model, and the ferric chloride model.
The ideal thrombosis model can summarize the clinically observed disease symptoms and pathological development process in patients of thrombosis. It has been demonstrated that NHPs have similar mechanisms to humans in terms of thrombosis, atherosclerosis, inflammation, and diabetes. Therefore, the NHP model of thrombosis is considered with the ability to highly mimic human pathology and provide reliable information for evaluating the antithrombotic efficacy of drugs in preclinical experiments.
Fig.1 Pathology of ventricular free wall (V) attache by intracardiac thrombus (T) in Mustached Tamarins (Saguinus mystax) of intracardiac thrombosis (hematoxylin and eosin staining). (Gozalo, et al., 2011)
To better assist the thrombosis research, Creative Biolabs provides the well-established and verified NHP model of thrombosis. The model characterization and drug evaluation can be executed by readouts including but not limited to bleeding time determination, thrombus weight measurement, blood loss analysis, prothrombin time, activated partial thromboplastin time determination, and complete blood count (CBC). If you are interested in our NHP model of thrombosis, please feel free to contact us for more information. The scientists of Creative Biolabs are willing to work with you, provide scientific assistance for your study projects, and ensure the smooth progress of your projects. We are your trusty CRO partner in your preclinical drug development.
Creative Biolabs offers various Cardiovascular Disease Models you may be interested in:
Reference
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