With many years of providing non-human primate (NHP) disease models, Creative Biolabs has accumulated lots of experience and valuable scientific data on primates. With the fully-equipped facilities, a professional R&D team, and the standardization management system, we have advanced many preclinical non-GLP projects of our clients based on our pharmacology and pharmacodynamics (PD/PK) platform.
Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. The main feature of hypertension is increased systemic arterial blood pressure including systolic and/or diastolic blood pressure (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg). Factors that induce hypertension include genetics, mental and environmental influences, age, living habits, drugs, and other diseases. Clinically, hypertension is often accompanied by functional or organic damage to the heart, brain, kidney, and other organs.
Hypertension is a complicated multi-factor disease. The present experimental hypertension models can simulate the hypertension response observed in hypertensive patients. These models can not only help researchers understand the etiology, disease development, and progression of hypertension, but can also be used to evaluate and screen the potential anti-hypertensive drugs. The hypertension models are mainly divided into the following five categories: genetical hypertension models (e.g., SHR rat, Dahl salt-sensitive rats, and other transgenic animals); endocrine hypertension models (e.g., DOCA-induced hypertension model); environmental hypertension models (e.g., stress-induced hypertension model); pharmacological hypertension models (e.g., L-NAME-induced hypertension model); renal hypertension models (e.g., two-kidney one-clip hypertension model, one-kidney one-clip hypertension model, and two-kidney two-clip hypertension model).
It is known that there are significant differences between humans and experimental animals regarding various aspects, such as genetics, physiology, anatomy, behavior, environmental conditions, etc. In particular, the differences between humans and widely used rodents have forced researchers to establish hypertension models using other experimental animals, such as NHPs. The major advantage of NHPs is that they are similar to humans in terms of anatomy, physiology, and hemodynamics. In addition, compared with small animals (such as rodents), NHPs have similar pathophysiology of hypertension to humans. NHPs are also suitable for the linear study of the hemodynamics of long-term elevated blood pressure, which can meet the scientific research requirements of multiple blood sampling.
Fig.1 A rhesus monkey of chronic ocular hypertension model. (Tu, et al., 2019)
With much experience in the NHP disease model establishment, Creative Biolabs provides the well-established NHP model of hypertension. Moreover, the available readouts include cuff blood pressure measurement, rhythm analysis, hemodynamic measurement, histopathological examination, etc. for improving the understanding of the pathogenesis, prevention, and treatment of hypertension.
If you are interested in the NHP model of hypertension or have any questions about the utilization of this model, please feel free to contact us for more information. The scientists of Creative Biolabs are willing to work with you and provide scientific assistance for your study projects. We are your trustworthy CRO partner.
Creative Biolabs offers various Cardiovascular Disease Models you may be interested in:
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