Creative Biolabs is a professional CRO company, who has accumulated rich experience based on our pharmacology and pharmacodynamics (PD/PK) platform. We deeply understand the importance of primate models in drug development, thus, have established diverse disease models on non-human primates (NHPs). Our NHP disease models are verified and stable, and many clients have adopted our NHP disease models for their projects.
Arrhythmia, characterized by abnormal heartbeats, can occur alone or along with other cardiovascular diseases. The prognosis of an arrhythmia is related to the etiology, progression, and whether it leads to severe blood flow disorder. This disease can cause heart failure by gradually involving it or sudden death due to sudden onset.
The development of anti-arrhythmic drugs is of great significance, and the establishment of a suitable model is a prerequisite for developing new drugs. The arrhythmia can be replicated in vitro by the perfusion of an isolated heart or a certain part of the heart. The arrhythmia can also be replicated in vivo using live animals. The animals most commonly used in research are mice, rats, guinea pigs, rabbits, dogs, cats, pigs, goats, and NHPs. The present arrhythmia in vivo models includes models of bradyarrhythmia, models of tachyarrhythmia, models of atrial flutter/fibrillation, models of ventricular tachycardia/fibrillation, models of atrioventricular block, and models of respiratory sinus arrhythmia.
Fig.1 The Incidence of arrhythmia in male cynomolgus monkeys. (Chui, et al., 2012)
Animal models are essential research tools in basic research and preclinical experiments. There are different kinds of experimental animals, among which NHPs are the closest to humans in terms of heredity, anatomy, physiology, and biochemistry. Importantly, the cardiovascular system of NHPs and humans is similar. Therefore, more and more researchers utilize NHPs to establish arrhythmia models now.
Creative Biolabs provides well-established NHP models of arrhythmia. The efficacy evaluation of anti-arrhythmia drugs is supported by multiple readouts. The related analysis services include but not are limited to myocardial Na+-K+ATPase and Ca2+-Mg2+ATPase measurement, serum CK-MB and cTnl level measurement, histological examination, myocardial Cx43 expression quantification, IHC, Western Blotting, and ELISA.
If you are interested in the NHP model of arrhythmia or have any questions about this model, please feel free to contact us for further discussions. The scientists of Creative Biolabs will provide you with scientific assistance for your study projects. We are your trustworthy CRO partner.
Creative Biolabs offers various Cardiovascular Disease Models you may be interested in:
Reference
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