Creative Biolabs provides rodent models that have been extensively used in preclinical research and for target validation in drug discovery for cardiovascular diseases and diabetic complications. Particularly, we have the latest genetically engineered model creation technology platform encompassing the most comprehensive gene manipulation techniques, enabling us to provide customized solutions and to develop novel models for disease areas that may not be readily or easily standardized in the field.
Introduction of Cardiovascular Disease
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Dyslipidemia, characterized by elevated plasma cholesterol, especially low-density lipoprotein cholesterol (LDL-c) levels, has been shown to be one of the most potent risk factors for coronary heart disease (CHD). Statins have been used for years in the treatment of hypercholesterolemia and have been proven effective in reducing cardiovascular risks by inhibiting cholesterol synthesis and lowering LDL-c. However, a large portion of statin-treated patients still experience adverse coronary events and thus the discovery and development of new therapeutic agents using appropriate preclinical animal models are required. The most useful and valid species/strains for the study of cardiovascular disease appear to be small rodents including rats, and mice. Larger animals are potential models that share common characteristics with humans but are problematic due to factors such as cost and ethical considerations. Creative Biolabs provides a wide-ranging collection of rodent models to facilitate your cardiovascular disease research.
Atherosclerosis is a disease in which plaque builds up inside human arteries. Plasma lipoproteins, genetics and the hemodynamics of the blood flow in the artery all play important roles in the development of atherosclerosis. Creative Biolabs offers genetically engineered mouse models including transgenic and gene knockout models for the study of atherosclerosis and drug development.
Diabetic complications that are associated with Diabetes mellitus include chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease) and microvascular disorders (nephropathy, retinopathy, neuropathy). Creative Biolabs offers rodent models that are used for testing the efficacy and safety of different pharmacological therapies for the management of these complications.
Heart failure is characterized by reduced cardiac output and consequently. The heart is unable to meet perfusion demands of the body. Creative Biolabs offers myocardial ischemia-induced, pressure-overload, and chemically-induced heart failure models to evaluate novel therapies for the treatment of this disease.
Myocardial infarction occurs when myocardial ischemia exceeds a critical threshold and overwhelms myocardial cellular repair mechanisms designed to maintain normal operating function and homeostasis. Creative Biolabs conducts contract efficacy studies in surgical ligation models, chemically induced models, and genetically modified mice models of myocardial infarction.
Hypertension is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. Creative Biolabs has established a number of rodent hypertension models using different methods, including surgical hypertension, genetic hypertension models, and endocrine hypertension models.
Thrombosis refers to the formation of a blood clot inside a blood vessel, obstructing the blood flow. It may occur in veins (large diameter and small diameter) or in arteries. Creative Biolabs conducts contract efficacy studies in models for deep vein thrombosis (DVT) and arterial thrombosis. moreover, we use a number of analyzing techniques to evaluate the therapeutic efficacy of novel drugs. We can customize the models and study designs to suit the exact research needs of our clients.
At Creative Biolabs, our hands-on approach and our collaborative interactions with our clients means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting of your data to provide you with dependable, reproducible results. Contact us for more information or a detailed quote if you are interested in our services.
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