Musculoskeletal disorders, including osteoarthritis (OA), osteoporosis, rheumatoid arthritis (RA), have imposed an enormous social and economic burden on society, causing disability and substantial patient morbidity. Preclinical models for musculoskeletal disorders are critical for understanding the pathogenesis and the development of effective therapies. In this regard, Creative Biolabs provides a wide range of conventionally available rodent models and key technologies to help progress your novel therapeutic agents into the clinic.
Osteoarthritis (OA) is a complex joint disease that involves degeneration of cartilage, limited synovitis, subchondral bone changes, and osteophyte formation. For mimicking different aspects of human OA disease, various models are available from Creative Biolabs, including surgically- and chemically-induced rodent models. Moreover, we perform a number of assessments and customized study protocols that suit specific client needs.
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures. Creative Biolabs provides both standard ovariectomized and orchidectomized rodent models to simulate female and male osteoporosis, respectively. Moreover, our state-of-the-art facilities enable us to conduct a comprehensive list of assessments in testing the therapeutic efficacy of osteoporosis drug candidates.
Bone Healing Models
Creative Biolabs provides fracture models such as standard closed fracture models for assessing the safety and efficacy of systemic pharmaceuticals that might affect fracture healing. However, the healing capacity of large bone defects is limited, thus making it necessary to develop innovative therapies for bone regeneration and repair. As a result, bone defect models are generated to study the effects of bone substitutes, biologics or cell-based products on bone regeneration. Our site-specific rodent bone defect models include long bone defect models, calvarial bone defect models, and maxillofacial bone defect models.
Rheumatoid Arthritis Models
RA is a long-term autoimmune disorder that primarily affects joints. Rodent models of immune-mediated arthritis are commonly used to evaluate the mechanisms of inflammatory joint disease, as well as test the efficacy of anti-arthritic compounds. Creative Biolabs offers the most commonly used models for the purpose of preclinical in vivo drug evaluation, including:
Supported by a team of scientists and experts in the field of musculoskeletal research, Creative Biolabs is capable of offering a fully integrated service, including evaluation of safety and efficacy of orthopedic medical devices and biologics, musculoskeletal tissue healing, and biocompatibility.
Additionally, we can provide flexible and customizable study designs to develop both short and long-term animal studies that are fully compliant with regulatory agencies. Contact us today to discuss your project needs and experience the value of our expert service.
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