Diseases of the kidney and urinary system are causing many deaths every year, making it urgent to discover new therapeutics. Currently, the application of animal models in preclinical research of drug efficacy test is of great importance. With sufficient expertise in disease model establishment, Creative Biolabs provides a wide range of urological system disease models, including surgical models, nephrotoxic models, and immune-mediated models, as well as the most comprehensive services for drug discovery and efficacy testing of potential novel therapeutics.
Models of Glomerulonephritis
Human glomerulonephritis (GN) is a progressive inflammation of the glomeruli that can be caused by a variety of underlying disorders. Creative Biolabs provides models that mimic human mesangial proliferative glomerulonephritis (Thy-1 Nephritis model) and anti-GBM nephritis (Anti-GBM Disease Model).
Acute Kidney Failure (ARF) Models
ARF is a common and potentially life-threatening complication after ischemia/reperfusion and/or exposure to nephrotoxic agents, including cisplatin, gentamicin, NSAID, etc. It is a reversible condition in which there is a sudden decline in renal function, manifested by hourly/daily/weekly elevation in serum creatinine and blood urea nitrogen (BUN). Creative Biolabs offers ARF models induced by different toxins/drugs and surgery.
Chronic Kidney Disease (CKD) Models
CKD is defined as the progressive loss of kidney function over a period of months or years, which is a worldwide public health problem with rising incidence and prevalence. The main pathologies of CKD are glomerulosclerosis, tubulointerstitial inflammation, and fibrosis. Creative Biolabs provides rodent CKD models that has been studied extensively, including chemically-induced and surgically-induced models for the assessment of potential novel therapies.
Cystitis Models
Interstitial cystitis (IC), also called bladder pain syndrome (BPS), is a type of chronic condition caused by inflammation of the bladder wall. The clinical symptoms of IC are often involved with a constant condition of recurrent urinary frequency, nocturia, suprapubic and pelvic pain. Creative Biolabs provides rodent cystitis models induced by chemical irritants, such as cyclophosphamide, and lipopolysaccharide.
Systemic Lupus Erythematosus (SLE) Models
Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disorder characterized by high levels of autoantibody production and multi-organ tissue damage,including skin, kidney, heart, lungs, and joints. We provide both spontaneous SLE mouse models and induced models of Systemic lupus erythematosus (SLE) disease for preclinical studies as well as pathogenesis research.
Our scientific team will assist you from the initial experimental design to final data analysis, to ensure the most relevant and reliable results can be achieved. Various parameters or endpoints can be measured and analyzed. To be specific, examples of blood, urine, isolated glomeruli or tubules, and kidney tissue can be obtained, processed and analyzed by Creative Biolabs or sent directly to our clients. Other parameters that can be measured include, but are not limited to:
With a full understanding of the importance of choosing appropriate disease models based on a specific research objective, Creative Biolabs provides various and well-characterized urological system disease models. The serum, urine, and tissue samples of these models listed below can help you to select models and verify mechanisms. Please contact us for more information or a detailed quote.
Rodent Kidney Disease Models | Modeling | Species | Sample types | Catalog # | |||
Thy-1 Nephritis Models | 3-9 weeks | Mouse | Anti-mouse Thy-1 Mab | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ1 |
|
Rat | Sheep Anti-Rat Thymocyte (Anti-Thy-1) Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ2 |
|||
Fx1A Nephritis Models | 3-9 weeks | Rat | Sheep Anti-Rat Fx1A Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ3 |
|
Anti-Glomerular Basement Membrane (GBM) Nephritis Models | 3-9 weeks | Rat | Sheep Anti-Rat GBM Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ4 |
|
Adriamycin-Induced Nephropathy (AN) Rodent Models | 2 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ5 |
|
4 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ6 |
||
6 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ7 |
||
8 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ8 |
||
10 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ9 |
||
Cisplatin-Induced Acute Renal Failure Models | 3 days | C57BL/6 mouse | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ10 |
|
7 days | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ11 |
||
Acute Kidney Injury Models | 2K2C Models | 3 days | Mouse | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ12 |
2K1C Models | / | Mouse | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ13 |
|
1K1C Models | / | Mouse | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ14 |
|
Kidney Ischemic Reperfusion Injury Models | 30min I-72h R | Rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ15 |
|
45min I-72h R | Rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ16 |
||
60min I-72h R | Rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ17 |
||
Subcute & Chronic Kidney Ischemic Reperfusion Injury Models | 5/6 Nephrectomy Models | 4 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ18 |
8 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ19 |
||
12 weeks | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ20 |
||
2/3 Branches of Renal Artery Ligation Models | / | SD rat | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ21 |
|
Adenine Induced CKD Rat Models | 28 days | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ22 |
|
37days | SD rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ23 |
||
/ | Lewis rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ24 |
||
/ | Wistar rat | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ25 |
||
Unilateral Ureter Obstruction (UUO) Mouse Models | 14 days | C57BL/6 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ26 |
|
10 days | C57BL/6 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ27 |
||
7 days | C57BL/6 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ28 |
||
3 days | C57BL/6 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ29 |
||
1 day | C57BL/6 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ30 |
||
7 days | CD1 mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ31 |
||
2 weeks | Rat | Serum | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ32 |
||
Renal Transplant Models | 2 weeks | Rat | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ33 |
|
4 weeks | Rat | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ34 |
||
Diabetic nephropathy Models | Streptozotocin induced Type I Diabetes Models | / | Mouse | / | / | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ35 |
STZ-HFD-induced diabetic nephropathy Models | / | Mouse | Serum | Urine | Kidney [FFPE block] [ Slide] [Snap Frozen] |
ZAJJ-0723-JJ36 |
For Research Use Only.