Urological System Disease Modeling & Pharmacodynamics Services

Creative Biolabs provides a variety of advanced models, including rodent, large animal, and humanized models, to assess the efficacy of treatments for urological system diseases. These models are designed to support drug development and therapeutic evaluation, offering comprehensive solutions for preclinical research.

Introduction

The urological system encompasses the kidneys, bladder, ureters, and urethra, and diseases of this system can significantly impact overall health. Common urological disorders include urinary tract infections (UTIs), kidney stones, bladder cancer, interstitial cystitis, and benign prostatic hyperplasia (BPH). Kidney diseases like chronic kidney disease (CKD) and glomerulonephritis are also prevalent, often leading to renal failure. Urological cancers, such as bladder and prostate cancer, are major concerns due to their high incidence and significant impact on quality of life. These diseases can result from genetic, environmental, or lifestyle factors, and they often present with symptoms like frequent urination, pain, blood in the urine, or difficulty urinating. Early diagnosis and treatment are crucial to managing these conditions effectively and preventing complications such as kidney failure or metastasis in cancers.

Urological System Disease Models

Creative Biolabs offers a wide range of well-established models for urological system diseases, including models for urinary tract infections (UTIs), kidney stones, bladder cancer, benign prostatic hyperplasia (BPH), chronic kidney disease (CKD), and other urological disorders. These models are meticulously developed to mirror critical aspects of human urological diseases, providing a reliable platform for preclinical evaluation of therapeutic candidates. Our models come with comprehensive assessments of urological parameters such as kidney function, urinary biomarkers, bladder function, and tumor progression, offering valuable insights into the effects of potential treatments. Our expert team of scientists will guide you through every stage of the project, from experimental design to data analysis, ensuring high-quality and reproducible results. To learn more about the urological disease models available for preclinical research, please explore the links below:

Evaluation Platform

• Animals: Mouse, Rat, Hamster, Rabbit, Dog, NHPs.
• Measurements
  We offer a variety of measurements for evaluating drug efficacy in urological system disease models, utilizing a range of advanced technologies, including but not limited to:
  • General observations: body weight, urination frequency, urine color, presence of hematuria or proteinuria, and mortality rate.
  • Immunohistochemistry: infiltration of immune cells (e.g., T-cells, macrophages) in the kidney, bladder, and prostate tissues.
  • Cytokine profiling (e.g., ELISA): expression levels of inflammatory mediators such as TNF-α, IL-6, IL-1β, and IL-17 in urological tissues.
  • Urine analysis: proteinuria, urinary pH, and specific gravity.
  • Hematology analysis and serum biomarkers: serum creatinine, blood urea nitrogen (BUN), and kidney function indicators.
  • Gene/protein expression profiling: RT qPCR and Western blot techniques to assess the expression of kidney and bladder-specific markers, such as aquaporins, uroplakins, and pro-inflammatory cytokines.
  • Histopathology: evaluation of tissue damage and fibrosis in the kidney, bladder, and prostate through H&E, Masson's Trichrome staining, and fibrosis scoring.

In addition to the established urological disease models, our expertise extends to the development of novel animal models tailored to specific research needs, guided by literature and prior studies. Our scientific team is available to assist in experimental design, model selection, and data analysis, ensuring a customized and effective approach to your project at every stage.

Related Services

In addition to urological system disease models, we also offer comprehensive models for a wide range of related diseases. These models provide robust platforms for drug efficacy testing and disease mechanism studies.

Products

With a full understanding of the importance of choosing appropriate disease models based on a specific research objective, Creative Biolabs provides various and well-characterized urological system disease models. The serum, urine, and tissue samples of these models listed below can help you to select models and verify mechanisms. Please contact us for more information or a detailed quote.

Our Advantages

• Comprehensive Expertise: We offer a wide range of well-established and customized disease models, ensuring tailored solutions for your research needs.
• Advanced Technologies: Our cutting-edge methodologies, including advanced imaging, histology, and biomarker analysis, provide precise and reliable results.
• High-Quality Support: Our team of experienced scientists offers full support, from experimental design to data interpretation, ensuring a smooth and efficient research process.
• Proven Track Record: With a history of successful collaborations across multiple therapeutic areas, we deliver dependable and reproducible results that meet your research goals.
• Tailored Solutions: We develop novel models based on the latest literature and prior studies, adapting to specific research requirements for maximum relevance and impact.

Work with Us

Get in touch!

FAQs

1. 1. What types of disease models do you offer?

   We provide a wide range of well-established models for urological diseases, metabolic disorders, liver diseases, cardiovascular conditions, and more. These models are available for both rodent and large animal studies.

2. 2. How do I select the right model for my research?

   Our scientific team is here to assist you in selecting the most suitable model based on your research objectives. We offer expert guidance from experimental design to data analysis.

3. 3. Do you offer customized disease models?

   Yes, we can develop customized animal models tailored to your specific research needs, based on the latest scientific literature and prior studies.

4. 4. What technologies and assays are used to evaluate drug efficacy?

   We utilize advanced technologies such as immunohistochemistry, cytokine profiling, gene/protein expression analysis (RT-qPCR, Western blot), urine analysis, histopathology, and hematology to assess drug efficacy.

5. 5. Can your models be used for long-term studies?

   Yes, our models are designed for both short-term and long-term studies, providing flexibility to meet the specific timelines of your research.

6. 6. How do you ensure the quality and reliability of your models?

   We adhere to strict quality control standards in model development and ensure reproducibility through extensive validation and ongoing evaluation in preclinical studies.

Published Data

Reference

1. Feng, Daniel et al. "Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury." Scientific Reports vol. 9,1 16736. 13 Nov. 2019. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.1038/s41598-019-52961-5

For Research Use Only.