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FGFR1 & KLB Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H326 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FGFR1 Human KLB Human Inquiry
T-BSDB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FGFR1 Mouse KLB Mouse Inquiry
SCIGG-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scIgG) Human Single chain IgGs FGFR1 Human KLB Human Inquiry
SCIGG-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scIgG) Human Single chain IgGs FGFR1 Mouse KLB Mouse Inquiry
FVTIG-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FGFR1 Human KLB Human Inquiry
FVTIG-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FGFR1 Mouse KLB Mouse Inquiry
BSSG-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv-IgG) Human scFv-IgG FGFR1 Human KLB Human Inquiry
BSSG-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-IgG) Human scFv-IgG FGFR1 Mouse KLB Mouse Inquiry
IGLFV-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FGFR1 Human KLB Human Inquiry
IGLFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FGFR1 Mouse KLB Mouse Inquiry
BSGV-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (IgG-Fv) Human IgG-Fv FGFR1 Human KLB Human Inquiry
BSGV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG-Fv) Human IgG-Fv FGFR1 Mouse KLB Mouse Inquiry
BSDG-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Fv-IgG) Human Fv-IgG FGFR1 Human KLB Human Inquiry
BSDG-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fv-IgG) Human Fv-IgG FGFR1 Mouse KLB Mouse Inquiry
BABFV-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FGFR1 Human KLB Human Inquiry
BABFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FGFR1 Mouse KLB Mouse Inquiry
FABVC-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FGFR1 Human KLB Human Inquiry
FABVC-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FGFR1 Mouse KLB Mouse Inquiry
SCDBC-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FGFR1 Human KLB Human Inquiry
SCDBC-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FGFR1 Mouse KLB Mouse Inquiry
BSDBC-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FGFR1 Human KLB Human Inquiry
BSDBC-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FGFR1 Mouse KLB Mouse Inquiry
SCDBF-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FGFR1 Human KLB Human Inquiry
SCDBF-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FGFR1 Mouse KLB Mouse Inquiry
BSFVF-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FGFR1 Human KLB Human Inquiry
BSFVF-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FGFR1 Mouse KLB Mouse Inquiry
BSDBF-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FGFR1 Human KLB Human Inquiry
BSDBF-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FGFR1 Mouse KLB Mouse Inquiry
BSTF-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FGFR1 Human KLB Human Inquiry
BSTF-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FGFR1 Mouse KLB Mouse Inquiry
BSCFV-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv-Fc) Human scFv-Fc FGFR1 Human KLB Human Inquiry
BSCFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-Fc) Human scFv-Fc FGFR1 Mouse KLB Mouse Inquiry
MNAB-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Miniantibody) Human Miniantibody FGFR1 Human KLB Human Inquiry
MNAB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Miniantibody) Human Miniantibody FGFR1 Mouse KLB Mouse Inquiry
BSFC-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv-CH3) Human scFv-CH3 FGFR1 Human KLB Human Inquiry
BSFC-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-CH3) Human scFv-CH3 FGFR1 Mouse KLB Mouse Inquiry
BSCC-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FGFR1 Human KLB Human Inquiry
BSCC-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FGFR1 Mouse KLB Mouse Inquiry
BIBD-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Bibody) Human Bibody FGFR1 Human KLB Human Inquiry
BIBD-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Bibody) Human Bibody FGFR1 Mouse KLB Mouse Inquiry
FABFV-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Fab-Fv) Human Fab-Fv FGFR1 Human KLB Human Inquiry
FABFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-Fv) Human Fab-Fv FGFR1 Mouse KLB Mouse Inquiry
MiniB-H327 Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Minibody) Human Minibody FGFR1 Human KLB Human Inquiry
MiniB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Minibody) Human Minibody FGFR1 Mouse KLB Mouse Inquiry
SCDB-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FGFR1 Human KLB Human Inquiry
FABIG-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-IgG) Human Fab-IgG FGFR1 Human KLB Human Inquiry
TRIB-H328 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FGFR1 Human KLB Human Inquiry
BSIG-H326 Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG-IgG) Human IgG-IgG FGFR1 Human KLB Human Inquiry
CROSSAB-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (CrossMab) Human CrossMab FGFR1 Human KLB Human Inquiry
IGFV-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG-scFv) Human IgG-scFv FGFR1 Human KLB Human Inquiry
BSDB-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody) Human Diabody FGFR1 Human KLB Human Inquiry
BSFAB-H326 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem Fab) Human Tandem Fab FGFR1 Human KLB Human Inquiry
BSFV-H324 Recombinant Human Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem scFv) Human Tandem scFv FGFR1 Human KLB Human Inquiry
SCDB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FGFR1 Mouse KLB Mouse Inquiry
FABIG-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-IgG) Human Fab-IgG FGFR1 Mouse KLB Mouse Inquiry
TRIB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FGFR1 Mouse KLB Mouse Inquiry
BSIG-161 Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG-IgG) Human IgG-IgG FGFR1 Mouse KLB Mouse Inquiry
CROSSAB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (CrossMab) Human CrossMab FGFR1 Mouse KLB Mouse Inquiry
IGFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (IgG-scFv) Human IgG-scFv FGFR1 Mouse KLB Mouse Inquiry
BSDB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody) Human Diabody FGFR1 Mouse KLB Mouse Inquiry
BSFAB-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem Fab) Human Tandem Fab FGFR1 Mouse KLB Mouse Inquiry
BSFV-161 Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Tandem scFv) Human Tandem scFv FGFR1 Mouse KLB Mouse Inquiry

Background

Fig.1 The working mode of anti-FGFR1×anti-KLB bispecific antibody. (Creative Biolabs Original)

The metabolic hormone FGF21 activates extracellular signaling through a unique FGFR1/KLB receptor complex, thereby acting on adipose, hepatic, and pancreatic tissues to regulate glucose and lipid metabolism. FGFR1 is a transmembrane protein belonging to the family of receptor tyrosine kinases. As a signaling receptor for FGF21, FGFR1 is critical in regulating developmental and metabolic processes. Dysregulated FGFR signaling has been linked to the progression of severe metabolic diseases and human cancers. Klotho β (KLB), a transmembrane protein with 130 kD in size, is an obligate co-receptor for FGFR1. The absence of β-Klotho prevents the FGF21 from binding directly to FGFR. The anti-FGFR1×anti-KLB bispecific antibody (BsAb) is a highly selective agonist of the FGFR1/KLB receptor complex. This BsAb can ameliorate obesity-associated metabolic defects by mimicking the activity of FGF21, which could be used in research for type 2 diabetes management.

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