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SOST Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H315 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DKK1 Human SOST Human Inquiry
T-BSDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DKK1 Mouse SOST Mouse Inquiry
SCIGG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scIgG) Human Single chain IgGs DKK1 Human SOST Human Inquiry
SCIGG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scIgG) Human Single chain IgGs DKK1 Mouse SOST Mouse Inquiry
FVTIG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DKK1 Human SOST Human Inquiry
FVTIG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DKK1 Mouse SOST Mouse Inquiry
BSSG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-IgG) Human scFv-IgG DKK1 Human SOST Human Inquiry
BSSG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-IgG) Human scFv-IgG DKK1 Mouse SOST Mouse Inquiry
IGLFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DKK1 Human SOST Human Inquiry
IGLFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DKK1 Mouse SOST Mouse Inquiry
BSGV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (IgG-Fv) Human IgG-Fv DKK1 Mouse SOST Mouse Inquiry
BSGV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-Fv) Human IgG-Fv DKK1 Mouse SOST Mouse Inquiry
BSDG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fv-IgG) Human Fv-IgG DKK1 Human SOST Human Inquiry
BSDG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fv-IgG) Human Fv-IgG DKK1 Mouse SOST Mouse Inquiry
BABFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DKK1 Human SOST Human Inquiry
BABFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DKK1 Mouse SOST Mouse Inquiry
FABVC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DKK1 Human SOST Human Inquiry
FABVC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DKK1 Mouse SOST Mouse Inquiry
SCDBC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DKK1 Human SOST Human Inquiry
SCDBC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DKK1 Mouse SOST Mouse Inquiry
BSDBC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DKK1 Human SOST Human Inquiry
BSDBC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DKK1 Mouse SOST Mouse Inquiry
SCDBF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DKK1 Human SOST Human Inquiry
SCDBF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DKK1 Mouse SOST Mouse Inquiry
BSFVF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DKK1 Human SOST Human Inquiry
BSFVF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DKK1 Mouse SOST Mouse Inquiry
BSDBF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DKK1 Human SOST Human Inquiry
BSDBF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DKK1 Mouse SOST Mouse Inquiry
BSTF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DKK1 Mouse SOST Mouse Inquiry
BSTF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DKK1 Mouse SOST Mouse Inquiry
BSCFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-Fc) Human scFv-Fc DKK1 Mouse SOST Mouse Inquiry
BSCFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-Fc) Human scFv-Fc DKK1 Mouse SOST Mouse Inquiry
MNAB-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Miniantibody) Human Miniantibody DKK1 Mouse SOST Mouse Inquiry
MNAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Miniantibody) Human Miniantibody DKK1 Mouse SOST Mouse Inquiry
BSFC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-CH3) Human scFv-CH3 DKK1 Mouse SOST Mouse Inquiry
BSFC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH3) Human scFv-CH3 DKK1 Mouse SOST Mouse Inquiry
BSCC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DKK1 Mouse SOST Mouse Inquiry
BSCC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DKK1 Mouse SOST Mouse Inquiry
BIBD-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Bibody) Human Bibody DKK1 Mouse SOST Mouse Inquiry
BIBD-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Bibody) Human Bibody DKK1 Mouse SOST Mouse Inquiry
FABFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-Fv) Human Fab-Fv DKK1 Human SOST Human Inquiry
FABFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-Fv) Human Fab-Fv DKK1 Mouse SOST Mouse Inquiry
MiniB-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Minibody) Human Minibody DKK1 Human SOST Human Inquiry
MiniB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Minibody) Human Minibody DKK1 Mouse SOST Mouse Inquiry
SCDB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DKK1 Human SOST Human Inquiry
FABIG-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-IgG) Human Fab-IgG DKK1 Human SOST Human Inquiry
TRIB-H317 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DKK1 Human SOST Human Inquiry
BSIG-H315 Human Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-IgG) Human IgG-IgG DKK1 Human SOST Human Inquiry
CROSSAB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (CrossMab) Human CrossMab DKK1 Human SOST Human Inquiry
IGFV-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-scFv) Human IgG-scFv DKK1 Human SOST Human Inquiry
BSDB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody) Human Diabody DKK1 Human SOST Human Inquiry
BSFAB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Fab) Human Tandem Fab DKK1 Human SOST Human Inquiry
BSFV-H314 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv) Human Tandem scFv DKK1 Human SOST Human Inquiry
SCDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DKK1 Mouse SOST Mouse Inquiry
FABIG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-IgG) Human Fab-IgG DKK1 Mouse SOST Mouse Inquiry
TRIB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DKK1 Mouse SOST Mouse Inquiry
BSIG-148 Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-IgG) Human IgG-IgG DKK1 Mouse SOST Mouse Inquiry
CROSSAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (CrossMab) Human CrossMab DKK1 Mouse SOST Mouse Inquiry
IGFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-scFv) Human IgG-scFv DKK1 Mouse SOST Mouse Inquiry
BSDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody) Human Diabody DKK1 Mouse SOST Mouse Inquiry
BSFAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Fab) Human Tandem Fab DKK1 Mouse SOST Mouse Inquiry
BSFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv) Human Tandem scFv DKK1 Mouse SOST Mouse Inquiry

Background

SOST inhibits the Wnt signaling pathway. (Creative Biolabs Original)Fig.1 SOST inhibits the Wnt signaling pathway.

Sclerostin (SOST), a protein with a secreted signal peptide and a cystine knot motif, is encoded by the SOST gene. SOST's amino acid sequence is 20-24% related to the differential screening-selected gene aberrative in the neuroblastoma (DAN) family, which exhibits anti-bone morphogenetic protein (BMP) properties. Wnt/β-catenin signaling pathway regulates osteogenesis. SOST binding to LPR4 and LPR5/6 inhibits the Wnt signaling pathway, resulting in phosphorylation of β-catenin and subsequent degradation by the proteasome. SOST is involved in sclerosteosis as well as Van Buchholm disease (VBD). Sclerosteosis is caused by SOST gene mutations, while patients with VBD do not have SOST gene mutations. Instead, there is a 52kb deletion 35kb downstream of the SOST gene. This deletion region is a noncoding enhancer region necessary for the postnatal expression of SOST.

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