Creative Biolabs’ technical experts have successfully established the proprietary complement therapeutics system. We are looking forward to designing a strategy to develop the preparation of sCR1/TP10 for our clients. Our customer service team of Ph.D. biologist can add real value to your research projects.
Regulators of Complement
Complement is a central part of the innate immune system, forms a barrier and functions as a true safeguard system in order to maintain tissue integrity. The complement system is composed of approximately 40 proteins which are either integral membrane proteins or soluble plasma proteins. The fully activated system has deleterious effects. Therefore, the activation of this vital defense system is tightly regulated.
Because regulators of complement activation are natural modifiers of complement activities and prevent a host cell from attack by its own defense system, they have been considered for therapeutic use since the early stages of complement drug discovery. A first breakthrough was reached with the expression of a soluble form of complement receptor 1 (sCR1) 53. sCR1 showed promising results in the treatment of I/R injury and various other conditions in experimental animal models. Based on these results, sCR1 was developed as a therapeutic (TP10, Avant Immunotherapeutics) for use after coronary artery bypass graft surgery.
Fig. 1 The sCR1/TP10 regulates complement system.1
Here, with its advanced biology technology, Creative Biolabs has mastered experience and expertise in protein and antibody expression, purification and so on. Our protein generation system can further support rapid and high-throughput protein production. Our sCR1/TP10 (Avant Immunotherapeutics) Development Service can be tailor-designed to meet your specific needs and it is fast, reliable, and affordable. Our service including but not limited to:
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sCR1/TP10(Avant Immunotherapeutics) development
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Protein expression and purification
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Similar preparation development
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Other supports if clients need
What Do We Submit to You?
We will start the experiment immediately after receiving the raw materials and proof of payment you provided.
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The results obtained during the submission of the experiment include protein and plasmids (if you need).
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Lab Report: We will provide you with all the experimental results of each stage of the experiment in written and electronic form. Including the experimental data and analysis of each part: affinity determination results; sequencing and analysis of protein sequences.
If you are interested in using our sCR1/TP10 (Avant Immunotherapeutics) Service to support your clinical discovery and development program, please contact us for more details.
Related Product
Reference
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Jia, Changhao, Ying Tan, and Minghui Zhao. "The complement system and autoimmune diseases." Chronic Diseases and Translational Medicine 8.03 (2022): 184-190.
For Research Use Only.
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